Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2019-06-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2019-0013 |
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| author | Ajani Olayinka O. Nlebemuo Martins T. Adekoya Joseph A. Ogunniran Kehinde O. Siyanbola Tolutope O. Ajanaku Christiana O. |
| author_facet | Ajani Olayinka O. Nlebemuo Martins T. Adekoya Joseph A. Ogunniran Kehinde O. Siyanbola Tolutope O. Ajanaku Christiana O. |
| author_sort | Ajani Olayinka O. |
| collection | DOAJ |
| description | Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development. |
| first_indexed | 2024-12-22T13:36:38Z |
| format | Article |
| id | doaj.art-b3cb781af27e44a9927fb6a2cf3933ab |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-22T13:36:38Z |
| publishDate | 2019-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-b3cb781af27e44a9927fb6a2cf3933ab2022-12-21T18:24:02ZengSciendoActa Pharmaceutica1846-95582019-06-0169217719610.2478/acph-2019-0013acph-2019-0013Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agentsAjani Olayinka O.0Nlebemuo Martins T.1Adekoya Joseph A.2Ogunniran Kehinde O.3Siyanbola Tolutope O.4Ajanaku Christiana O.5Department of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaDepartment of Chemistry Covenant University, CST, Canaanland Km 10 Idiroko Road, P.M.B. 1023, Ota Ogun State, NigeriaSurpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.https://doi.org/10.2478/acph-2019-0013quinoxalineanticancer activitypharmacophore |
| spellingShingle | Ajani Olayinka O. Nlebemuo Martins T. Adekoya Joseph A. Ogunniran Kehinde O. Siyanbola Tolutope O. Ajanaku Christiana O. Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents Acta Pharmaceutica quinoxaline anticancer activity pharmacophore |
| title | Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| title_full | Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| title_fullStr | Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| title_full_unstemmed | Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| title_short | Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| title_sort | chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents |
| topic | quinoxaline anticancer activity pharmacophore |
| url | https://doi.org/10.2478/acph-2019-0013 |
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