Anti-cancer peptide-based therapeutic strategies in solid tumors
Abstract Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively. Result Introducing beneficia...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-022-00332-w |
| _version_ | 1819210080225067008 |
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| author | Mohsen Karami Fath Kimiya Babakhaniyan Maryam Zokaei Azadeh Yaghoubian Sadaf Akbari Mahdieh Khorsandi Asma Soofi Mohsen Nabi-Afjadi Hamidreza Zalpoor Fateme Jalalifar Ali Azargoonjahromi Zahra Payandeh Armina Alagheband Bahrami |
| author_facet | Mohsen Karami Fath Kimiya Babakhaniyan Maryam Zokaei Azadeh Yaghoubian Sadaf Akbari Mahdieh Khorsandi Asma Soofi Mohsen Nabi-Afjadi Hamidreza Zalpoor Fateme Jalalifar Ali Azargoonjahromi Zahra Payandeh Armina Alagheband Bahrami |
| author_sort | Mohsen Karami Fath |
| collection | DOAJ |
| description | Abstract Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively. Result Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology. Conclusion This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed. |
| first_indexed | 2024-12-23T06:05:29Z |
| format | Article |
| id | doaj.art-b3cded6f90184efd95436123a76c1d21 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-12-23T06:05:29Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-b3cded6f90184efd95436123a76c1d212022-12-21T17:57:34ZengBMCCellular & Molecular Biology Letters1425-81531689-13922022-04-0127112610.1186/s11658-022-00332-wAnti-cancer peptide-based therapeutic strategies in solid tumorsMohsen Karami Fath0Kimiya Babakhaniyan1Maryam Zokaei2Azadeh Yaghoubian3Sadaf Akbari4Mahdieh Khorsandi5Asma Soofi6Mohsen Nabi-Afjadi7Hamidreza Zalpoor8Fateme Jalalifar9Ali Azargoonjahromi10Zahra Payandeh11Armina Alagheband Bahrami12Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi UniversityDepartment of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical SciencesDepartment of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDepartment of Exercise Physiology, Central Tehran Branch, Islamic Azad UniversityFaculty of Pharmacy, Mashhad University of Medical SciencesDepartment of Biotechnology, Faculty of Pharmacy, Mashhad University of Medical SciencesDepartment of Physical Chemistry, School of Chemistry, College of Sciences, University of TehranDepartment of Biochemistry, Faculty of biological science, Tarbiat Modares UniversityAmerican Association of Kidney PatientsSchool of Medicine, Jiroft University of Medical SciencesShiraz University of Medical SciencesDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska InstituteDepartment of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesAbstract Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively. Result Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology. Conclusion This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.https://doi.org/10.1186/s11658-022-00332-wPeptide-based strategiesTumor-homing peptidesDrug deliveryTargeted delivery |
| spellingShingle | Mohsen Karami Fath Kimiya Babakhaniyan Maryam Zokaei Azadeh Yaghoubian Sadaf Akbari Mahdieh Khorsandi Asma Soofi Mohsen Nabi-Afjadi Hamidreza Zalpoor Fateme Jalalifar Ali Azargoonjahromi Zahra Payandeh Armina Alagheband Bahrami Anti-cancer peptide-based therapeutic strategies in solid tumors Cellular & Molecular Biology Letters Peptide-based strategies Tumor-homing peptides Drug delivery Targeted delivery |
| title | Anti-cancer peptide-based therapeutic strategies in solid tumors |
| title_full | Anti-cancer peptide-based therapeutic strategies in solid tumors |
| title_fullStr | Anti-cancer peptide-based therapeutic strategies in solid tumors |
| title_full_unstemmed | Anti-cancer peptide-based therapeutic strategies in solid tumors |
| title_short | Anti-cancer peptide-based therapeutic strategies in solid tumors |
| title_sort | anti cancer peptide based therapeutic strategies in solid tumors |
| topic | Peptide-based strategies Tumor-homing peptides Drug delivery Targeted delivery |
| url | https://doi.org/10.1186/s11658-022-00332-w |
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