The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma
MM is a hematological neoplasm that is still considered an incurable disease. Besides established genetic alterations, recent studies have shown that MM pathogenesis is also characterized by epigenetic aberrations, such as the gain of de novo active chromatin marks in promoter and enhancer regions a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/8/1976 |
| _version_ | 1797537071851634688 |
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| author | Arantxa Carrasco-León Ane Amundarain Nahia Gómez-Echarte Felipe Prósper Xabier Agirre |
| author_facet | Arantxa Carrasco-León Ane Amundarain Nahia Gómez-Echarte Felipe Prósper Xabier Agirre |
| author_sort | Arantxa Carrasco-León |
| collection | DOAJ |
| description | MM is a hematological neoplasm that is still considered an incurable disease. Besides established genetic alterations, recent studies have shown that MM pathogenesis is also characterized by epigenetic aberrations, such as the gain of de novo active chromatin marks in promoter and enhancer regions and extensive DNA hypomethylation of intergenic regions, highlighting the relevance of these non-coding genomic regions. A recent study described how long non-coding RNAs (lncRNAs) correspond to 82% of the MM transcriptome and an increasing number of studies have demonstrated the importance of deregulation of lncRNAs in MM. In this review we focus on the deregulated lncRNAs in MM, including their biological or functional mechanisms, their role as biomarkers to improve the prognosis and monitoring of MM patients, and their participation in drug resistance. Furthermore, we also discuss the evidence supporting the role of lncRNAs as therapeutic targets through different novel RNA-based strategies. |
| first_indexed | 2024-03-10T12:09:54Z |
| format | Article |
| id | doaj.art-b3cef08a353b407ca2caae08624a2daa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:09:54Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b3cef08a353b407ca2caae08624a2daa2023-11-21T16:17:43ZengMDPI AGCancers2072-66942021-04-01138197610.3390/cancers13081976The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple MyelomaArantxa Carrasco-León0Ane Amundarain1Nahia Gómez-Echarte2Felipe Prósper3Xabier Agirre4Área de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, SpainÁrea de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, SpainÁrea de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, SpainÁrea de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, SpainÁrea de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, Universidad de Navarra, Avenida Pío XII-55, 31008 Pamplona, SpainMM is a hematological neoplasm that is still considered an incurable disease. Besides established genetic alterations, recent studies have shown that MM pathogenesis is also characterized by epigenetic aberrations, such as the gain of de novo active chromatin marks in promoter and enhancer regions and extensive DNA hypomethylation of intergenic regions, highlighting the relevance of these non-coding genomic regions. A recent study described how long non-coding RNAs (lncRNAs) correspond to 82% of the MM transcriptome and an increasing number of studies have demonstrated the importance of deregulation of lncRNAs in MM. In this review we focus on the deregulated lncRNAs in MM, including their biological or functional mechanisms, their role as biomarkers to improve the prognosis and monitoring of MM patients, and their participation in drug resistance. Furthermore, we also discuss the evidence supporting the role of lncRNAs as therapeutic targets through different novel RNA-based strategies.https://www.mdpi.com/2072-6694/13/8/1976lncRNAsmultiple myelomaRNA-based therapy |
| spellingShingle | Arantxa Carrasco-León Ane Amundarain Nahia Gómez-Echarte Felipe Prósper Xabier Agirre The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma Cancers lncRNAs multiple myeloma RNA-based therapy |
| title | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma |
| title_full | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma |
| title_fullStr | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma |
| title_full_unstemmed | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma |
| title_short | The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma |
| title_sort | role of lncrnas in the pathobiology and clinical behavior of multiple myeloma |
| topic | lncRNAs multiple myeloma RNA-based therapy |
| url | https://www.mdpi.com/2072-6694/13/8/1976 |
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