Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe
Ischemic stroke is one of the leading causes of disability and mortality. The collaterals provide an alternative pathway to preserve the ischemic brain tissue, and determine the penumbra range, where the neurons are salvageable. Therefore, accurately monitoring the collaterals and identifying the pe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523006263 |
| _version_ | 1797671485995745280 |
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| author | Peisen Zhang Wenyue Li Chuang Liu Lichong Zhu Junwei Cheng Runxin Pang Yue Lan Meng Qin Yi Hou |
| author_facet | Peisen Zhang Wenyue Li Chuang Liu Lichong Zhu Junwei Cheng Runxin Pang Yue Lan Meng Qin Yi Hou |
| author_sort | Peisen Zhang |
| collection | DOAJ |
| description | Ischemic stroke is one of the leading causes of disability and mortality. The collaterals provide an alternative pathway to preserve the ischemic brain tissue, and determine the penumbra range, where the neurons are salvageable. Therefore, accurately monitoring the collaterals and identifying the penumbra are crucial. Herein, a low-immunogenic nanoprobe-based MRI strategy is developed to simultaneously identify the infarct core, collaterals distribution, and ischemic penumbra distributions. The low-immunogenic nanoprobe was constructed by covalently attaching self-peptide on the surface of biocompatible Fe3O4 nanoparticles as a stealth coating. Both in vitro and in vivo experiments clearly revealed that the nanoprobes can effectively avoid capture by macrophages, and exhibited prolonged blood half-life to continuously enhance the contrast of blood vessels in a longer time window in susceptibility-weighted imaging (SWI), which enabled the delineation of the collaterals and ischemic penumbra. More importantly, combined with the diffusion-weighted imaging (DWI), the infarct core, collateral vessels, and the ischemic penumbra range can be identified simultaneously. In this context, the stroke progress including infarct core growth, collateral vessel formation, and penumbra distribution, can be better understood. This nanoprobe-based strategy thus offers a practical route for precise diagnosis of ischemic stroke, which remains a challenge for conventional MRI strategies. |
| first_indexed | 2024-03-11T21:16:14Z |
| format | Article |
| id | doaj.art-b3d0431989a34b25844bf2f16e2e6afc |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T21:16:14Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-b3d0431989a34b25844bf2f16e2e6afc2023-09-29T04:43:23ZengElsevierMaterials & Design0264-12752023-09-01233112211Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobePeisen Zhang0Wenyue Li1Chuang Liu2Lichong Zhu3Junwei Cheng4Runxin Pang5Yue Lan6Meng Qin7Yi Hou8Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China; College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, ChinaDepartment of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China; Guangzhou Key Laboratory of Aging Frailty and Neurorehabilitation, Guangzhou, Guangdong 510180, China; Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China (Y. Lan); College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, China (M. Qin and Y. Hou).College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, China; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China (Y. Lan); College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, China (M. Qin and Y. Hou).College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, China; Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China (Y. Lan); College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 10029, China (M. Qin and Y. Hou).Ischemic stroke is one of the leading causes of disability and mortality. The collaterals provide an alternative pathway to preserve the ischemic brain tissue, and determine the penumbra range, where the neurons are salvageable. Therefore, accurately monitoring the collaterals and identifying the penumbra are crucial. Herein, a low-immunogenic nanoprobe-based MRI strategy is developed to simultaneously identify the infarct core, collaterals distribution, and ischemic penumbra distributions. The low-immunogenic nanoprobe was constructed by covalently attaching self-peptide on the surface of biocompatible Fe3O4 nanoparticles as a stealth coating. Both in vitro and in vivo experiments clearly revealed that the nanoprobes can effectively avoid capture by macrophages, and exhibited prolonged blood half-life to continuously enhance the contrast of blood vessels in a longer time window in susceptibility-weighted imaging (SWI), which enabled the delineation of the collaterals and ischemic penumbra. More importantly, combined with the diffusion-weighted imaging (DWI), the infarct core, collateral vessels, and the ischemic penumbra range can be identified simultaneously. In this context, the stroke progress including infarct core growth, collateral vessel formation, and penumbra distribution, can be better understood. This nanoprobe-based strategy thus offers a practical route for precise diagnosis of ischemic stroke, which remains a challenge for conventional MRI strategies.http://www.sciencedirect.com/science/article/pii/S0264127523006263Acute ischemic strokeCollateralsPenumbraNanoprobeMRI |
| spellingShingle | Peisen Zhang Wenyue Li Chuang Liu Lichong Zhu Junwei Cheng Runxin Pang Yue Lan Meng Qin Yi Hou Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe Materials & Design Acute ischemic stroke Collaterals Penumbra Nanoprobe MRI |
| title | Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe |
| title_full | Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe |
| title_fullStr | Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe |
| title_full_unstemmed | Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe |
| title_short | Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe |
| title_sort | simultaneous identifying the infarct core collaterals and penumbra after acute ischemic stroke with a low immunogenic mri nanoprobe |
| topic | Acute ischemic stroke Collaterals Penumbra Nanoprobe MRI |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523006263 |
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