Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway

Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway

Abstract Background Interleukin-6 (IL-6) has been reported to be critical in oral squamous cell carcinoma (OSCC). However, the set of pathways that IL-6 might activate in OSCC are not fully understood. Methods IL-6 and Sox4 expressions were first determined with RT-qPCR, ELISA, Western blot, or immu...

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Bibliographic Details
Main Authors: Li Xiao, Xue Li, Peilin Cao, Wei Fei, Hao Zhou, Na Tang, Yi Liu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
IL-6
Oral squamous cell carcinoma
NLRP3 inflammasome
JAK2
STAT3
Sox4
Online Access:https://doi.org/10.1186/s13046-022-02376-4

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