The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.634512/full |
| _version_ | 1819141445589663744 |
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| author | Soudeh Ghafouri-Fard Atefe Abak Mahdi Mohaqiq Mahdi Mohaqiq Hamed Shoorei Mohammad Taheri |
| author_facet | Soudeh Ghafouri-Fard Atefe Abak Mahdi Mohaqiq Mahdi Mohaqiq Hamed Shoorei Mohammad Taheri |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities. |
| first_indexed | 2024-12-22T11:54:34Z |
| format | Article |
| id | doaj.art-b3d51302209e4d6687fbf859a0796930 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T11:54:34Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b3d51302209e4d6687fbf859a07969302022-12-21T18:26:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.634512634512The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of NeoplasiaSoudeh Ghafouri-Fard0Atefe Abak1Mahdi Mohaqiq2Mahdi Mohaqiq3Hamed Shoorei4Mohammad Taheri5Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranSchool of Advancement, Centennial College, Ashtonbee Campus, Toronto, ON, CanadaWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, United StatesDepartment of Anatomical Sciences, Faculty of Medicine, Biranjd University of Medical Sciences, Birjand, IranUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranThe insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities.https://www.frontiersin.org/articles/10.3389/fcell.2021.634512/fullIGFmiRNAlncRNAexpressiondisorders |
| spellingShingle | Soudeh Ghafouri-Fard Atefe Abak Mahdi Mohaqiq Mahdi Mohaqiq Hamed Shoorei Mohammad Taheri The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia Frontiers in Cell and Developmental Biology IGF miRNA lncRNA expression disorders |
| title | The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia |
| title_full | The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia |
| title_fullStr | The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia |
| title_full_unstemmed | The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia |
| title_short | The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia |
| title_sort | interplay between non coding rnas and insulin like growth factor signaling in the pathogenesis of neoplasia |
| topic | IGF miRNA lncRNA expression disorders |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.634512/full |
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