Migraine attacks the Basal Ganglia
<p>Abstract</p> <p>Background</p> <p>With time, episodes of migraine headache afflict patients with increased frequency, longer duration and more intense pain. While episodic migraine may be defined as 1-14 attacks per month, there are no clear-cut phases defined, and t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-09-01
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| Series: | Molecular Pain |
| Subjects: | |
| Online Access: | http://www.molecularpain.com/content/7/1/71 |
| _version_ | 1811244469711798272 |
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| author | Bigal Marcelo Brawn Jennifer Pendse Gautam Nutile Lauren Becerra Lino Maleki Nasim Burstein Rami Borsook David |
| author_facet | Bigal Marcelo Brawn Jennifer Pendse Gautam Nutile Lauren Becerra Lino Maleki Nasim Burstein Rami Borsook David |
| author_sort | Bigal Marcelo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>With time, episodes of migraine headache afflict patients with increased frequency, longer duration and more intense pain. While episodic migraine may be defined as 1-14 attacks per month, there are no clear-cut phases defined, and those patients with low frequency may progress to high frequency episodic migraine and the latter may progress into chronic daily headache (> 15 attacks per month). The pathophysiology of this progression is completely unknown. Attempting to unravel this phenomenon, we used high field (human) brain imaging to compare functional responses, functional connectivity and brain morphology in patients whose migraine episodes did not progress (LF) to a matched (gender, age, age of onset and type of medication) group of patients whose migraine episodes progressed (HF).</p> <p>Results</p> <p>In comparison to LF patients, responses to pain in HF patients were significantly lower in the caudate, putamen and pallidum. Paradoxically, associated with these lower responses in HF patients, gray matter volume of the right and left caudate nuclei were significantly larger than in the LF patients. Functional connectivity analysis revealed additional differences between the two groups in regard to response to pain.</p> <p>Conclusions</p> <p>Supported by current understanding of basal ganglia role in pain processing, the findings suggest a significant role of the basal ganglia in the pathophysiology of the episodic migraine.</p> |
| first_indexed | 2024-04-12T14:25:36Z |
| format | Article |
| id | doaj.art-b3d54e75fdea4c78abb1be996b37194f |
| institution | Directory Open Access Journal |
| issn | 1744-8069 |
| language | English |
| last_indexed | 2024-04-12T14:25:36Z |
| publishDate | 2011-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Pain |
| spelling | doaj.art-b3d54e75fdea4c78abb1be996b37194f2022-12-22T03:29:28ZengSAGE PublishingMolecular Pain1744-80692011-09-01717110.1186/1744-8069-7-71Migraine attacks the Basal GangliaBigal MarceloBrawn JenniferPendse GautamNutile LaurenBecerra LinoMaleki NasimBurstein RamiBorsook David<p>Abstract</p> <p>Background</p> <p>With time, episodes of migraine headache afflict patients with increased frequency, longer duration and more intense pain. While episodic migraine may be defined as 1-14 attacks per month, there are no clear-cut phases defined, and those patients with low frequency may progress to high frequency episodic migraine and the latter may progress into chronic daily headache (> 15 attacks per month). The pathophysiology of this progression is completely unknown. Attempting to unravel this phenomenon, we used high field (human) brain imaging to compare functional responses, functional connectivity and brain morphology in patients whose migraine episodes did not progress (LF) to a matched (gender, age, age of onset and type of medication) group of patients whose migraine episodes progressed (HF).</p> <p>Results</p> <p>In comparison to LF patients, responses to pain in HF patients were significantly lower in the caudate, putamen and pallidum. Paradoxically, associated with these lower responses in HF patients, gray matter volume of the right and left caudate nuclei were significantly larger than in the LF patients. Functional connectivity analysis revealed additional differences between the two groups in regard to response to pain.</p> <p>Conclusions</p> <p>Supported by current understanding of basal ganglia role in pain processing, the findings suggest a significant role of the basal ganglia in the pathophysiology of the episodic migraine.</p>http://www.molecularpain.com/content/7/1/71HeadachePainMigrainefMRIFunctional ConnectivityMorphometryGray Matter VolumeBasal Ganglia |
| spellingShingle | Bigal Marcelo Brawn Jennifer Pendse Gautam Nutile Lauren Becerra Lino Maleki Nasim Burstein Rami Borsook David Migraine attacks the Basal Ganglia Molecular Pain Headache Pain Migraine fMRI Functional Connectivity Morphometry Gray Matter Volume Basal Ganglia |
| title | Migraine attacks the Basal Ganglia |
| title_full | Migraine attacks the Basal Ganglia |
| title_fullStr | Migraine attacks the Basal Ganglia |
| title_full_unstemmed | Migraine attacks the Basal Ganglia |
| title_short | Migraine attacks the Basal Ganglia |
| title_sort | migraine attacks the basal ganglia |
| topic | Headache Pain Migraine fMRI Functional Connectivity Morphometry Gray Matter Volume Basal Ganglia |
| url | http://www.molecularpain.com/content/7/1/71 |
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