New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study
Abstract Background Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified. Methods A retrospective longitudinal cohort study was conducted using the Taiwan Longit...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-09416-4 |
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| author | Chung-Che Lu Tee-Tau Eric Nyam Chung-Han Ho Jinn-Rung Kuo Chung-Ching Chio Jhi-Joung Wang Che-Chuan Wang |
| author_facet | Chung-Che Lu Tee-Tau Eric Nyam Chung-Han Ho Jinn-Rung Kuo Chung-Ching Chio Jhi-Joung Wang Che-Chuan Wang |
| author_sort | Chung-Che Lu |
| collection | DOAJ |
| description | Abstract Background Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified. Methods A retrospective longitudinal cohort study was conducted using the Taiwan Longitudinal Health Insurance Database between January 2000 and December 2011. A total of 35,306 patients were initially enrolled, and 14,795 patients with mild TBI and 14,795 patients with moderate/severe TBI were matched using the National Health Insurance Research Database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted for potential confounding factors. Results After matching, the results showed that patients with moderate/severe TBI had a high mortality rate (17.7% vs. 10.4%) and shorter time interval from TBI to death (mean 3.6 years vs. 5.8 years). No differences were observed in cancer incidence (4.1% vs. 4.1%) or risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significant higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients. The top 15 most common cancers showed that mild TBI patients had a higher percentage of head and neck cancer. The overall mortality rate in all TBI patients diagnosed with cancer was about 50%, and the cancer-specific mortality is approximately 85% in death of TBI patients with cancer. Conclusions We concluded that the incidence risk of a new cancer diagnosis and mortality risk of TBI patients with cancer between the mild TBI and moderate/severe TBI patients were not significantly different. |
| first_indexed | 2024-12-13T20:07:55Z |
| format | Article |
| id | doaj.art-b3d8c9eb0b2141f58f1b6fcf052c44a7 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T20:07:55Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-b3d8c9eb0b2141f58f1b6fcf052c44a72022-12-21T23:32:58ZengBMCBMC Cancer1471-24072022-03-0122111110.1186/s12885-022-09416-4New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based studyChung-Che Lu0Tee-Tau Eric Nyam1Chung-Han Ho2Jinn-Rung Kuo3Chung-Ching Chio4Jhi-Joung Wang5Che-Chuan Wang6Departments of Neurosurgery, Chi-Mei Medical CenterDepartments of Neurosurgery, Chi-Mei Medical CenterDepartments of Medical Research, Chi-Mei Medical CenterDepartments of Neurosurgery, Chi-Mei Medical CenterDepartments of Neurosurgery, Chi-Mei Medical CenterDepartments of Medical Research, Chi-Mei Medical CenterDepartments of Neurosurgery, Chi-Mei Medical CenterAbstract Background Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified. Methods A retrospective longitudinal cohort study was conducted using the Taiwan Longitudinal Health Insurance Database between January 2000 and December 2011. A total of 35,306 patients were initially enrolled, and 14,795 patients with mild TBI and 14,795 patients with moderate/severe TBI were matched using the National Health Insurance Research Database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted for potential confounding factors. Results After matching, the results showed that patients with moderate/severe TBI had a high mortality rate (17.7% vs. 10.4%) and shorter time interval from TBI to death (mean 3.6 years vs. 5.8 years). No differences were observed in cancer incidence (4.1% vs. 4.1%) or risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significant higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients. The top 15 most common cancers showed that mild TBI patients had a higher percentage of head and neck cancer. The overall mortality rate in all TBI patients diagnosed with cancer was about 50%, and the cancer-specific mortality is approximately 85% in death of TBI patients with cancer. Conclusions We concluded that the incidence risk of a new cancer diagnosis and mortality risk of TBI patients with cancer between the mild TBI and moderate/severe TBI patients were not significantly different.https://doi.org/10.1186/s12885-022-09416-4Traumatic brain injury (TBI)Mild TBIModerate/severe TBICancerMortalityPopulation-based |
| spellingShingle | Chung-Che Lu Tee-Tau Eric Nyam Chung-Han Ho Jinn-Rung Kuo Chung-Ching Chio Jhi-Joung Wang Che-Chuan Wang New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study BMC Cancer Traumatic brain injury (TBI) Mild TBI Moderate/severe TBI Cancer Mortality Population-based |
| title | New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study |
| title_full | New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study |
| title_fullStr | New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study |
| title_full_unstemmed | New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study |
| title_short | New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study |
| title_sort | new diagnosis of cancer in mild and moderate severe traumatic brain injury patients in a 12 year population based study |
| topic | Traumatic brain injury (TBI) Mild TBI Moderate/severe TBI Cancer Mortality Population-based |
| url | https://doi.org/10.1186/s12885-022-09416-4 |
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