Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient
A 12-year-old ASA I female patient underwent correction of posterior scoliosis of dorsolumbar spine under total intravenous anesthesia using a combination of remifentanil and propofol. Induced hypotension was maintained between 55 and 65 mmHg. Intraoperatively, patient received a single injection of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Pain |
| Subjects: | |
| Online Access: | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=1;spage=52;epage=54;aulast=Khan |
| _version_ | 1819292370027413504 |
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| author | Rashid M Khan Sujit Nair Adil Sulaiman Al-Kharusi Haris Aziz Naresh Kaul |
| author_facet | Rashid M Khan Sujit Nair Adil Sulaiman Al-Kharusi Haris Aziz Naresh Kaul |
| author_sort | Rashid M Khan |
| collection | DOAJ |
| description | A 12-year-old ASA I female patient underwent correction of posterior scoliosis of dorsolumbar spine under total intravenous anesthesia using a combination of remifentanil and propofol. Induced hypotension was maintained between 55 and 65 mmHg. Intraoperatively, patient received a single injection of 1.0 g paracetamol. Surgery lasted 6 h and 40 min and was essentially uneventful. A follow-up investigation in the intensive care unit 6 h after the surgery revealed alanine transaminase levels of 547 I/U. This increased to 924 I/U on the 2 nd postoperative day after the patient received 500 mg per-rectal paracetamol. Stopping administration of paracetamol restored alanine transaminase level to normal without needing N-acetylcysteine. |
| first_indexed | 2024-12-24T03:53:27Z |
| format | Article |
| id | doaj.art-b3d8d0eb0f184b0698fbdab6197c39cb |
| institution | Directory Open Access Journal |
| issn | 0970-5333 |
| language | English |
| last_indexed | 2024-12-24T03:53:27Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj.art-b3d8d0eb0f184b0698fbdab6197c39cb2022-12-21T17:16:31ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332015-01-01291525410.4103/0970-5333.145949Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patientRashid M KhanSujit NairAdil Sulaiman Al-KharusiHaris AzizNaresh KaulA 12-year-old ASA I female patient underwent correction of posterior scoliosis of dorsolumbar spine under total intravenous anesthesia using a combination of remifentanil and propofol. Induced hypotension was maintained between 55 and 65 mmHg. Intraoperatively, patient received a single injection of 1.0 g paracetamol. Surgery lasted 6 h and 40 min and was essentially uneventful. A follow-up investigation in the intensive care unit 6 h after the surgery revealed alanine transaminase levels of 547 I/U. This increased to 924 I/U on the 2 nd postoperative day after the patient received 500 mg per-rectal paracetamol. Stopping administration of paracetamol restored alanine transaminase level to normal without needing N-acetylcysteine.http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=1;spage=52;epage=54;aulast=KhanAlanine N-acetylcysteinehepatic toxicityparacetamol |
| spellingShingle | Rashid M Khan Sujit Nair Adil Sulaiman Al-Kharusi Haris Aziz Naresh Kaul Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient Indian Journal of Pain Alanine N-acetylcysteine hepatic toxicity paracetamol |
| title | Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| title_full | Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| title_fullStr | Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| title_full_unstemmed | Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| title_short | Significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| title_sort | significantly raised alanine aminotransferase level following single dose of intravenous paracetamol in a healthy patient |
| topic | Alanine N-acetylcysteine hepatic toxicity paracetamol |
| url | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=1;spage=52;epage=54;aulast=Khan |
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