The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes

The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes

Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxor...

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Bibliographic Details
Main Authors: F. Misiti, B. Giardina, A. Mordente, M.E. Clementi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2003-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Anthracyclines
Doxorubicinol
Doxorubicin
Aglycone metabolite
Pentose phosphate pathway
[13C]-NMR spectroscopy
Hemoglobin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200005

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