Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score.
BACKGROUND AND AIM: Metabolic syndrome (MetS), albuminuria, and the Framingham Risk Score (FRS) are significant predictors for cardiovascular disease (CVD). However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ES...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4012957?pdf=render |
| _version_ | 1819231734704635904 |
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| author | Jiun-Chi Huang Szu-Chia Chen Ming-Yen Lin Jer-Ming Chang Shang-Jyh Hwang Jer-Chia Tsai Hung-Chun Chen |
| author_facet | Jiun-Chi Huang Szu-Chia Chen Ming-Yen Lin Jer-Ming Chang Shang-Jyh Hwang Jer-Chia Tsai Hung-Chun Chen |
| author_sort | Jiun-Chi Huang |
| collection | DOAJ |
| description | BACKGROUND AND AIM: Metabolic syndrome (MetS), albuminuria, and the Framingham Risk Score (FRS) are significant predictors for cardiovascular disease (CVD). However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ESRD) are unclear. We investigated the association of relatives of hemodialysis (HD) patients with MetS, albuminuria, and the FRS. METHODS: One hundred and sixty-six relatives of HD patients and 374 age- and sex- matched community controls were enrolled. MetS was defined using the Adult Treatment Panel III for Asians. Albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g. CVD risk was evaluated by the FRS. RESULTS: A significantly higher prevalence of MetS (19.9% vs. 12.5%, P = 0.026), albuminuria (12.7% vs. 5.1%, P = 0.002) and high FRS risk ≥ 10% of 10-year risk (15.7% vs. 8.5%, P = 0.013) was found in relatives of HD patients compared to their counterpart controls. In multivariate analysis, being relatives of HD patients (vs. controls) was an independent determinant for MetS (odds ratio [OR], 1.785; 95% confidence interval [CI], 1.045 to 3.050), albuminuria (OR, 2.891; 95% CI, 1.431 to 5.841), and high FRS risk (OR, 1.863; 95% CI, 1.015 to 3.418). Higher low-density lipoprotein cholesterol (OR, 1.034; 95% CI, 1.017 to 1.052) and betel nut chewing (OR, 13.994; 95% CI, 3.384 to 57.871) were independent determinants for having a high FRS risk in relatives of HD patients. CONCLUSIONS: Being relatives of HD patients was independently associated with MetS, albuminuria and high FRS risk, suggesting family members of ESRD patients may have higher CVD risks through the interactions of renal risk factors. Proactive surveillance of these CVD predictors and preventive strategies should be targeted to this high-risk population. |
| first_indexed | 2024-12-23T11:49:40Z |
| format | Article |
| id | doaj.art-b3dd016d9bdb40f88c3b5838e2917868 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T11:49:40Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b3dd016d9bdb40f88c3b5838e29178682022-12-21T17:48:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9636210.1371/journal.pone.0096362Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score.Jiun-Chi HuangSzu-Chia ChenMing-Yen LinJer-Ming ChangShang-Jyh HwangJer-Chia TsaiHung-Chun ChenBACKGROUND AND AIM: Metabolic syndrome (MetS), albuminuria, and the Framingham Risk Score (FRS) are significant predictors for cardiovascular disease (CVD). However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ESRD) are unclear. We investigated the association of relatives of hemodialysis (HD) patients with MetS, albuminuria, and the FRS. METHODS: One hundred and sixty-six relatives of HD patients and 374 age- and sex- matched community controls were enrolled. MetS was defined using the Adult Treatment Panel III for Asians. Albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g. CVD risk was evaluated by the FRS. RESULTS: A significantly higher prevalence of MetS (19.9% vs. 12.5%, P = 0.026), albuminuria (12.7% vs. 5.1%, P = 0.002) and high FRS risk ≥ 10% of 10-year risk (15.7% vs. 8.5%, P = 0.013) was found in relatives of HD patients compared to their counterpart controls. In multivariate analysis, being relatives of HD patients (vs. controls) was an independent determinant for MetS (odds ratio [OR], 1.785; 95% confidence interval [CI], 1.045 to 3.050), albuminuria (OR, 2.891; 95% CI, 1.431 to 5.841), and high FRS risk (OR, 1.863; 95% CI, 1.015 to 3.418). Higher low-density lipoprotein cholesterol (OR, 1.034; 95% CI, 1.017 to 1.052) and betel nut chewing (OR, 13.994; 95% CI, 3.384 to 57.871) were independent determinants for having a high FRS risk in relatives of HD patients. CONCLUSIONS: Being relatives of HD patients was independently associated with MetS, albuminuria and high FRS risk, suggesting family members of ESRD patients may have higher CVD risks through the interactions of renal risk factors. Proactive surveillance of these CVD predictors and preventive strategies should be targeted to this high-risk population.http://europepmc.org/articles/PMC4012957?pdf=render |
| spellingShingle | Jiun-Chi Huang Szu-Chia Chen Ming-Yen Lin Jer-Ming Chang Shang-Jyh Hwang Jer-Chia Tsai Hung-Chun Chen Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. PLoS ONE |
| title | Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. |
| title_full | Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. |
| title_fullStr | Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. |
| title_full_unstemmed | Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. |
| title_short | Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score. |
| title_sort | association of relatives of hemodialysis patients with metabolic syndrome albuminuria and framingham risk score |
| url | http://europepmc.org/articles/PMC4012957?pdf=render |
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