Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review
Macrophage activation syndrome (MAS) is a rare and severe complication of Kawasaki disease (KD). The clinical feature, early diagnosis and treatment options, and prognosis need to be further determined in patients with KD complicated with MAS. In this report, we retrospectively analyzed three KD pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00423/full |
| _version_ | 1819067025394237440 |
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| author | Ping Jin Yong Luo Xi Liu Jinji Xu Chunyi Liu |
| author_facet | Ping Jin Yong Luo Xi Liu Jinji Xu Chunyi Liu |
| author_sort | Ping Jin |
| collection | DOAJ |
| description | Macrophage activation syndrome (MAS) is a rare and severe complication of Kawasaki disease (KD). The clinical feature, early diagnosis and treatment options, and prognosis need to be further determined in patients with KD complicated with MAS. In this report, we retrospectively analyzed three KD patients complicated with MAS who were treated in pediatric intensive care units (PICU) and reviewed the relevant literatures. We find that being male, being age over 2 years old, incomplete KD, intravenous immunoglobulin (IVIG) non-responder, or persistent fever greater than 10 days are all highly associated with occurrence of MAS. Additional work-ups should be performed promptly in patient with above predisposing factors to rule out complication of MAS. Patients with KD complicated with MAS are at a higher risk of having coronary artery involvement or aneurysm formation, which can be reversed with timely treatment. Early identification and prompt treatment are key points for improving the prognosis of KD patients complicated with MAS. |
| first_indexed | 2024-12-21T16:11:41Z |
| format | Article |
| id | doaj.art-b3ddf368231141c9a1420207a587f11b |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-21T16:11:41Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-b3ddf368231141c9a1420207a587f11b2022-12-21T18:57:47ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-11-01710.3389/fped.2019.00423482028Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature ReviewPing Jin0Yong Luo1Xi Liu2Jinji Xu3Chunyi Liu4Pediatric Intensive Care Unit, Baoan Maternal and Child Health Hospital, College of Medicine, Jinan University, Shenzhen, ChinaPediatric Intensive Care Unit, Baoan Maternal and Child Health Hospital, College of Medicine, Jinan University, Shenzhen, ChinaDepartment of Cardiology, Baoan Maternal and Child Health Hospital, College of Medicine, Jinan University, Shenzhen, ChinaPediatric Intensive Care Unit, Baoan Maternal and Child Health Hospital, College of Medicine, Jinan University, Shenzhen, ChinaPediatric Intensive Care Unit, Baoan Maternal and Child Health Hospital, College of Medicine, Jinan University, Shenzhen, ChinaMacrophage activation syndrome (MAS) is a rare and severe complication of Kawasaki disease (KD). The clinical feature, early diagnosis and treatment options, and prognosis need to be further determined in patients with KD complicated with MAS. In this report, we retrospectively analyzed three KD patients complicated with MAS who were treated in pediatric intensive care units (PICU) and reviewed the relevant literatures. We find that being male, being age over 2 years old, incomplete KD, intravenous immunoglobulin (IVIG) non-responder, or persistent fever greater than 10 days are all highly associated with occurrence of MAS. Additional work-ups should be performed promptly in patient with above predisposing factors to rule out complication of MAS. Patients with KD complicated with MAS are at a higher risk of having coronary artery involvement or aneurysm formation, which can be reversed with timely treatment. Early identification and prompt treatment are key points for improving the prognosis of KD patients complicated with MAS.https://www.frontiersin.org/article/10.3389/fped.2019.00423/fullKawasaki diseasecomplicationmacrophage activation syndromecoronary arterychildren |
| spellingShingle | Ping Jin Yong Luo Xi Liu Jinji Xu Chunyi Liu Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review Frontiers in Pediatrics Kawasaki disease complication macrophage activation syndrome coronary artery children |
| title | Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review |
| title_full | Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review |
| title_fullStr | Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review |
| title_full_unstemmed | Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review |
| title_short | Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review |
| title_sort | kawasaki disease complicated with macrophage activation syndrome case reports and literature review |
| topic | Kawasaki disease complication macrophage activation syndrome coronary artery children |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00423/full |
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