Chemical constituents and pharmacological profile of Gunnera manicata L. extracts
Gunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2014-03-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100015&lng=en&tlng=en |
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| author | Kristiane de Cássia Mariotti Roselena Silvestri Schuh Jéssica de Matos Nunes Sabrina Pinto Salamoni Gabriela Meirelles Fabiano Barreto Gilsane Lino Von Poser Rodrigo Bustos Singer Eliane Dallegrave Sueli Teresinha Van Der Sand Renata Pereira Limberger |
| author_facet | Kristiane de Cássia Mariotti Roselena Silvestri Schuh Jéssica de Matos Nunes Sabrina Pinto Salamoni Gabriela Meirelles Fabiano Barreto Gilsane Lino Von Poser Rodrigo Bustos Singer Eliane Dallegrave Sueli Teresinha Van Der Sand Renata Pereira Limberger |
| author_sort | Kristiane de Cássia Mariotti |
| collection | DOAJ |
| description | Gunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemical and pharmacological properties of South American Gunnera species. Therefore this study aimed at assessing the phytochemical and pharmacological profiles of aqueous and methanol Brazilian G. manicata extracts. The results showed that antimicrobial activity in an agar diffusion assay was effective against Staphylococcus aureus and Candida albicans . Phenolic compounds were investigated by liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) and all extracts presented gallic acid and only the methanol extract obtained from the leaves exhibited hyperoside. Rutin, quercetin and chlorogenic acid were not found in the samples analysed. Total phenolic content was higher in methanol extract and total flavonoid content was low in all extracts. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical test, and all samples presented good to moderate antioxidant activity. These results encourage complementary studies on the chemical composition of the plant extracts focusing on isolation and structure elucidation of their active compounds. |
| first_indexed | 2024-04-12T18:47:38Z |
| format | Article |
| id | doaj.art-b3dfa7938a254de0bc6fb49ef0156d5b |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T18:47:38Z |
| publishDate | 2014-03-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b3dfa7938a254de0bc6fb49ef0156d5b2022-12-22T03:20:34ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902014-03-0150114715410.1590/S1984-82502014000100015S1984-82502014000100015Chemical constituents and pharmacological profile of Gunnera manicata L. extractsKristiane de Cássia MariottiRoselena Silvestri SchuhJéssica de Matos NunesSabrina Pinto SalamoniGabriela MeirellesFabiano BarretoGilsane Lino Von PoserRodrigo Bustos SingerEliane DallegraveSueli Teresinha Van Der SandRenata Pereira LimbergerGunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemical and pharmacological properties of South American Gunnera species. Therefore this study aimed at assessing the phytochemical and pharmacological profiles of aqueous and methanol Brazilian G. manicata extracts. The results showed that antimicrobial activity in an agar diffusion assay was effective against Staphylococcus aureus and Candida albicans . Phenolic compounds were investigated by liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) and all extracts presented gallic acid and only the methanol extract obtained from the leaves exhibited hyperoside. Rutin, quercetin and chlorogenic acid were not found in the samples analysed. Total phenolic content was higher in methanol extract and total flavonoid content was low in all extracts. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical test, and all samples presented good to moderate antioxidant activity. These results encourage complementary studies on the chemical composition of the plant extracts focusing on isolation and structure elucidation of their active compounds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100015&lng=en&tlng=enGunnera manicata L./fitoquímicaGunnera manicata L./farmacognosiaGunneraceae /farmacognosiaGunnera manicata L./extratos/efeito antimicrobianoGunnera manicata L./extratos/ atividade antioxidanteGunnera manicata L./extratos/ensaio antimicrobiano |
| spellingShingle | Kristiane de Cássia Mariotti Roselena Silvestri Schuh Jéssica de Matos Nunes Sabrina Pinto Salamoni Gabriela Meirelles Fabiano Barreto Gilsane Lino Von Poser Rodrigo Bustos Singer Eliane Dallegrave Sueli Teresinha Van Der Sand Renata Pereira Limberger Chemical constituents and pharmacological profile of Gunnera manicata L. extracts Brazilian Journal of Pharmaceutical Sciences Gunnera manicata L./fitoquímica Gunnera manicata L./farmacognosia Gunneraceae /farmacognosia Gunnera manicata L./extratos/efeito antimicrobiano Gunnera manicata L./extratos/ atividade antioxidante Gunnera manicata L./extratos/ensaio antimicrobiano |
| title | Chemical constituents and pharmacological profile of Gunnera manicata L. extracts |
| title_full | Chemical constituents and pharmacological profile of Gunnera manicata L. extracts |
| title_fullStr | Chemical constituents and pharmacological profile of Gunnera manicata L. extracts |
| title_full_unstemmed | Chemical constituents and pharmacological profile of Gunnera manicata L. extracts |
| title_short | Chemical constituents and pharmacological profile of Gunnera manicata L. extracts |
| title_sort | chemical constituents and pharmacological profile of gunnera manicata l extracts |
| topic | Gunnera manicata L./fitoquímica Gunnera manicata L./farmacognosia Gunneraceae /farmacognosia Gunnera manicata L./extratos/efeito antimicrobiano Gunnera manicata L./extratos/ atividade antioxidante Gunnera manicata L./extratos/ensaio antimicrobiano |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100015&lng=en&tlng=en |
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