Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis

Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis

The P106L mutation in the human myeloproliferative leukemia virus oncogene (MPL) was shown to be associated with hereditary thrombocythemia in Arabs. The clinical and bone marrow (BM) features of P106L mutation are unknown. Genetic databases at two tertiary hospitals in Saudi Arabia were searched to...

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Bibliographic Details
Main Authors: Musa Alzahrani, Saeed Al Turki, Waleed Al Rajban, Fatimah Alshalati, Fahad Almodaihsh, Khadega A. Abuelgasim, Bader Alahmari, Thamer Al Bogami, Osama Ali, Talal Al Harbi, Mohammed A. AlBalwi, Maram Alotaibi, Aamer Aleem, Ahmed Al Asker, Areej Al Mugairi
Format: Article
Language:English
Published: Taylor & Francis Group 2022-11-01
Series:Platelets
Subjects:
familial thrombocythemia
hereditary thrombocytosis
mpl
Online Access:http://dx.doi.org/10.1080/09537104.2022.2091773

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