Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii
Increasing multiple drug resistant (MDR) strains of Acinetobacter baumannii has aggravated curiosity in development of alternative therapy. Bacteriophages are often considered as alternative agents for controlling A. baumannii infections. In the present study two lytic phages for MDR A. baumannii we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=5;spage=373;epage=380;aulast=Ghajavand |
| _version_ | 1818864634347651072 |
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| author | Hasan Ghajavand Bahram Nasr Esfahani Asghar Havaei Hossein Fazeli Reyhaneh Jafari Sharareh Moghim |
| author_facet | Hasan Ghajavand Bahram Nasr Esfahani Asghar Havaei Hossein Fazeli Reyhaneh Jafari Sharareh Moghim |
| author_sort | Hasan Ghajavand |
| collection | DOAJ |
| description | Increasing multiple drug resistant (MDR) strains of Acinetobacter baumannii has aggravated curiosity in development of alternative therapy. Bacteriophages are often considered as alternative agents for controlling A. baumannii infections. In the present study two lytic phages for MDR A. baumannii were isolated and their efficacy and host ranges were evaluated. The phages were isolated from hospital wastewater. Electron microscopy revealed that IsfAB78 might belong to Myoviridae and IsfAB39 to Podoviridae. Initial characterization of phages showed that they have narrow host range and failed to infect relative and non- relative bacteria. Both phages decreased the A. baumannii turbidity significantly, indicating that these isolated phages may be considered as candidates for phage therapy. |
| first_indexed | 2024-12-19T10:34:46Z |
| format | Article |
| id | doaj.art-b3e4697e41224f3dbc7bcef800fbd63e |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-19T10:34:46Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-b3e4697e41224f3dbc7bcef800fbd63e2022-12-21T20:25:39ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142017-01-0112537338010.4103/1735-5362.213982Isolation of bacteriophages against multidrug resistant Acinetobacter baumanniiHasan GhajavandBahram Nasr EsfahaniAsghar HavaeiHossein FazeliReyhaneh JafariSharareh MoghimIncreasing multiple drug resistant (MDR) strains of Acinetobacter baumannii has aggravated curiosity in development of alternative therapy. Bacteriophages are often considered as alternative agents for controlling A. baumannii infections. In the present study two lytic phages for MDR A. baumannii were isolated and their efficacy and host ranges were evaluated. The phages were isolated from hospital wastewater. Electron microscopy revealed that IsfAB78 might belong to Myoviridae and IsfAB39 to Podoviridae. Initial characterization of phages showed that they have narrow host range and failed to infect relative and non- relative bacteria. Both phages decreased the A. baumannii turbidity significantly, indicating that these isolated phages may be considered as candidates for phage therapy.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=5;spage=373;epage=380;aulast=Ghajavandphage therapy; multidrug resistant acinetobacter baumannii; bacteriophage |
| spellingShingle | Hasan Ghajavand Bahram Nasr Esfahani Asghar Havaei Hossein Fazeli Reyhaneh Jafari Sharareh Moghim Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii Research in Pharmaceutical Sciences phage therapy; multidrug resistant acinetobacter baumannii; bacteriophage |
| title | Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii |
| title_full | Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii |
| title_fullStr | Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii |
| title_full_unstemmed | Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii |
| title_short | Isolation of bacteriophages against multidrug resistant Acinetobacter baumannii |
| title_sort | isolation of bacteriophages against multidrug resistant acinetobacter baumannii |
| topic | phage therapy; multidrug resistant acinetobacter baumannii; bacteriophage |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=5;spage=373;epage=380;aulast=Ghajavand |
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