Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling.

Neuroimmune gene induction is involved in many brain pathologies including addiction. Although increased expression of proinflammatory cytokines has been found in ethanol-treated mouse brain and rat brain slice cultures as well as in post-mortem human alcoholic brain, the mechanisms remain elusive....

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Bibliographic Details
Main Authors: Jian Y Zou, Fulton T Crews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3925099?pdf=render