The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases
Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases. Autophagy is a crucial adaptive cellular response to stress st...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/9/382 |
| _version_ | 1797579536833970176 |
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| author | Yuqin Wang Yongnan Li Hong Ding Dan Li Wanxi Shen Xiaowei Zhang |
| author_facet | Yuqin Wang Yongnan Li Hong Ding Dan Li Wanxi Shen Xiaowei Zhang |
| author_sort | Yuqin Wang |
| collection | DOAJ |
| description | Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases. Autophagy is a crucial adaptive cellular response to stress stimuli. Mounting evidence suggests a strong correlation between Sirtuins and autophagy, potentially involving cross-regulation and crosstalk. Sirtuin-mediated autophagy plays a crucial regulatory role in some cardiovascular diseases, including atherosclerosis, ischemia/reperfusion injury, hypertension, heart failure, diabetic cardiomyopathy, and drug-induced myocardial damage. In this context, we summarize the research advancements pertaining to various Sirtuins involved in autophagy and the molecular mechanisms regulating autophagy. We also elucidate the biological function of Sirtuins across diverse cardiovascular diseases and further discuss the development of novel drugs that regulate Sirtuin-mediated autophagy. |
| first_indexed | 2024-03-10T22:38:30Z |
| format | Article |
| id | doaj.art-b3e5e4cfbd824d81ad78fe2a49941900 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T22:38:30Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-b3e5e4cfbd824d81ad78fe2a499419002023-11-19T11:16:39ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-09-0110938210.3390/jcdd10090382The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular DiseasesYuqin Wang0Yongnan Li1Hong Ding2Dan Li3Wanxi Shen4Xiaowei Zhang5The Second Clinical Medical College, Lanzhou University, Lanzhou 730106, ChinaDepartment of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730031, ChinaDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, ChinaThe Second Clinical Medical College, Lanzhou University, Lanzhou 730106, ChinaQinghai Provincial People’s Hospital, Qinghai University, Xining 810007, ChinaDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, ChinaSirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases. Autophagy is a crucial adaptive cellular response to stress stimuli. Mounting evidence suggests a strong correlation between Sirtuins and autophagy, potentially involving cross-regulation and crosstalk. Sirtuin-mediated autophagy plays a crucial regulatory role in some cardiovascular diseases, including atherosclerosis, ischemia/reperfusion injury, hypertension, heart failure, diabetic cardiomyopathy, and drug-induced myocardial damage. In this context, we summarize the research advancements pertaining to various Sirtuins involved in autophagy and the molecular mechanisms regulating autophagy. We also elucidate the biological function of Sirtuins across diverse cardiovascular diseases and further discuss the development of novel drugs that regulate Sirtuin-mediated autophagy.https://www.mdpi.com/2308-3425/10/9/382SirtuinsautophagyFOXOsAMPKmTORcardiovascular diseases |
| spellingShingle | Yuqin Wang Yongnan Li Hong Ding Dan Li Wanxi Shen Xiaowei Zhang The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases Journal of Cardiovascular Development and Disease Sirtuins autophagy FOXOs AMPK mTOR cardiovascular diseases |
| title | The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases |
| title_full | The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases |
| title_fullStr | The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases |
| title_full_unstemmed | The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases |
| title_short | The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases |
| title_sort | current state of research on sirtuin mediated autophagy in cardiovascular diseases |
| topic | Sirtuins autophagy FOXOs AMPK mTOR cardiovascular diseases |
| url | https://www.mdpi.com/2308-3425/10/9/382 |
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