An Improved Automated Setup for Solubility Determination of Drugs
Background: Solubility of a drug/drug candidate is an essential information in the pharmaceutical area. Classical solubility determination method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility determination setup based on a laser moni...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2016-09-01
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| Series: | Pharmaceutical Sciences |
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| Online Access: | http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_1041_20160501193051 |
| _version_ | 1818392398488666112 |
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| author | Ahmad Ghanbari 1, Yashar Sarbaz, Vahid Jouyban-Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban |
| author_facet | Ahmad Ghanbari 1, Yashar Sarbaz, Vahid Jouyban-Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban |
| author_sort | Ahmad Ghanbari 1, Yashar Sarbaz, Vahid Jouyban-Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban |
| collection | DOAJ |
| description | Background: Solubility of a drug/drug candidate is an essential information in the pharmaceutical area. Classical solubility determination method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility determination setup based on a laser monitoring technique. Methods: In a previously developed setup, drug powder was added to a given quantity of the solvent which made some troubles in practical applications. The present work reports another setup which adds solvent to a given mass of the drug. The validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at two temperatures in water and ethanol mixtures with the corresponding data from the literature. Results: The results reveal that the improved setup could overcome the limitations of the previously developed setup and could be used for drug solubility determination. Conclusion: The improved setup overcomes the troubles made in the previous setup and could be used in generating large amount of solubility data to be used in the pharmaceutical industry. |
| first_indexed | 2024-12-14T05:28:47Z |
| format | Article |
| id | doaj.art-b3e7e4de718a4709a5d8e6d80cc68ebe |
| institution | Directory Open Access Journal |
| issn | 2383-2886 2383-2886 |
| language | English |
| last_indexed | 2024-12-14T05:28:47Z |
| publishDate | 2016-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj.art-b3e7e4de718a4709a5d8e6d80cc68ebe2022-12-21T23:15:25ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862383-28862016-09-0122321021410.15171/PS.2016.33An Improved Automated Setup for Solubility Determination of DrugsAhmad Ghanbari 1, Yashar Sarbaz, Vahid Jouyban-Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban Background: Solubility of a drug/drug candidate is an essential information in the pharmaceutical area. Classical solubility determination method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility determination setup based on a laser monitoring technique. Methods: In a previously developed setup, drug powder was added to a given quantity of the solvent which made some troubles in practical applications. The present work reports another setup which adds solvent to a given mass of the drug. The validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at two temperatures in water and ethanol mixtures with the corresponding data from the literature. Results: The results reveal that the improved setup could overcome the limitations of the previously developed setup and could be used for drug solubility determination. Conclusion: The improved setup overcomes the troubles made in the previous setup and could be used in generating large amount of solubility data to be used in the pharmaceutical industry.http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_1041_20160501193051Aqueous solubilityDeterminationDrugLaser monitoring |
| spellingShingle | Ahmad Ghanbari 1, Yashar Sarbaz, Vahid Jouyban-Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban An Improved Automated Setup for Solubility Determination of Drugs Pharmaceutical Sciences Aqueous solubility Determination Drug Laser monitoring |
| title | An Improved Automated Setup for Solubility Determination of Drugs |
| title_full | An Improved Automated Setup for Solubility Determination of Drugs |
| title_fullStr | An Improved Automated Setup for Solubility Determination of Drugs |
| title_full_unstemmed | An Improved Automated Setup for Solubility Determination of Drugs |
| title_short | An Improved Automated Setup for Solubility Determination of Drugs |
| title_sort | improved automated setup for solubility determination of drugs |
| topic | Aqueous solubility Determination Drug Laser monitoring |
| url | http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_1041_20160501193051 |
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