Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma
We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221300712200048X |
| _version_ | 1828732326295633920 |
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| author | Ryan Kronen David R. Ziehr Ashley E.D. Kane Paul A. VanderLaan Cyrus A. Kholdani Robert W. Hallowell |
| author_facet | Ryan Kronen David R. Ziehr Ashley E.D. Kane Paul A. VanderLaan Cyrus A. Kholdani Robert W. Hallowell |
| author_sort | Ryan Kronen |
| collection | DOAJ |
| description | We present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was treated with cyclophosphamide, bortezomib, and dexamethasone but died prior to completing treatment. His case is unique for the amyloid deposition found in all three lung compartments with clear pathophysiologic manifestations of each compartment, and the rapid disease progression that led to respiratory failure and death. |
| first_indexed | 2024-04-12T17:59:35Z |
| format | Article |
| id | doaj.art-b3e86ffe8edb4149bd0ec71b4baaee4d |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-12T17:59:35Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-b3e86ffe8edb4149bd0ec71b4baaee4d2022-12-22T03:22:12ZengElsevierRespiratory Medicine Case Reports2213-00712022-01-0137101626Pulmonary amyloidosis as the presenting finding in a patient with multiple myelomaRyan Kronen0David R. Ziehr1Ashley E.D. Kane2Paul A. VanderLaan3Cyrus A. Kholdani4Robert W. Hallowell5Department of Medicine, University of Washington, Seattle, WA, USA; Corresponding author. Department of Medicine University of Washington, 1959 NE Pacific Street Seattle, WA, 98195, USA.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USADepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USADepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USADivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USAWe present the case of a 58-year-old man who presented with dyspnea, cough, and weight loss and was ultimately diagnosed with pulmonary amyloidosis and multiple myeloma. Diagnosis was achieved with a lung biopsy which showed AL amyloid deposits involving the interstitium, vessels, and airway. He was treated with cyclophosphamide, bortezomib, and dexamethasone but died prior to completing treatment. His case is unique for the amyloid deposition found in all three lung compartments with clear pathophysiologic manifestations of each compartment, and the rapid disease progression that led to respiratory failure and death.http://www.sciencedirect.com/science/article/pii/S221300712200048XMultiple myelomaPulmonary amyloidosisLight chain (AL) amyloidosisCase report |
| spellingShingle | Ryan Kronen David R. Ziehr Ashley E.D. Kane Paul A. VanderLaan Cyrus A. Kholdani Robert W. Hallowell Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma Respiratory Medicine Case Reports Multiple myeloma Pulmonary amyloidosis Light chain (AL) amyloidosis Case report |
| title | Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| title_full | Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| title_fullStr | Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| title_full_unstemmed | Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| title_short | Pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| title_sort | pulmonary amyloidosis as the presenting finding in a patient with multiple myeloma |
| topic | Multiple myeloma Pulmonary amyloidosis Light chain (AL) amyloidosis Case report |
| url | http://www.sciencedirect.com/science/article/pii/S221300712200048X |
| work_keys_str_mv | AT ryankronen pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma AT davidrziehr pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma AT ashleyedkane pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma AT paulavanderlaan pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma AT cyrusakholdani pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma AT robertwhallowell pulmonaryamyloidosisasthepresentingfindinginapatientwithmultiplemyeloma |