Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer
Currently, precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver cancer. Herein, we synthesized Mn-doped Ti MOFs (Mn–Ti MOFs) nanosheets by in-situ doping method and applied them for microwave therapy. Infrared th...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23001135 |
| _version_ | 1797799949509853184 |
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| author | Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu |
| author_facet | Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu |
| author_sort | Qiongyu Qin |
| collection | DOAJ |
| description | Currently, precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver cancer. Herein, we synthesized Mn-doped Ti MOFs (Mn–Ti MOFs) nanosheets by in-situ doping method and applied them for microwave therapy. Infrared thermal imaging results indicate Mn–Ti MOFs can rapidly increase the temperature of normal saline, attributing to the porous structure improving microwave-induced ion collision frequency. Moreover, Mn–Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn doping. At the same time, Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging (r2/r1 = 2.315). Further, results on HepG2 tumor-bearing mice prove that microwave-triggered Mn–Ti MOFs nearly eradicate the tumors after 14 days of treatment. Our study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer. |
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| format | Article |
| id | doaj.art-b3ea30ce19ea449b9d5aa6b9fd8eb27a |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-13T04:27:12Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-b3ea30ce19ea449b9d5aa6b9fd8eb27a2023-06-20T04:20:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-09-01277281Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancerQiongyu Qin0Ming Yang1Yu Shi2Haijing Cui3Chunshu Pan4Wenzhi Ren5Aiguo Wu6Jianqing Hu7School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, PR ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo, 315201, PR ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo, 315201, PR ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo, 315201, PR ChinaDepartment of Radiology, Ningbo No. 2 Hospital, Ningbo, 315010, PR ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo, 315201, PR China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516000, PR ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo, 315201, PR China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516000, PR China; Corresponding author. Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516000, PR China.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, PR China; Corresponding author. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, PR China.Currently, precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver cancer. Herein, we synthesized Mn-doped Ti MOFs (Mn–Ti MOFs) nanosheets by in-situ doping method and applied them for microwave therapy. Infrared thermal imaging results indicate Mn–Ti MOFs can rapidly increase the temperature of normal saline, attributing to the porous structure improving microwave-induced ion collision frequency. Moreover, Mn–Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn doping. At the same time, Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging (r2/r1 = 2.315). Further, results on HepG2 tumor-bearing mice prove that microwave-triggered Mn–Ti MOFs nearly eradicate the tumors after 14 days of treatment. Our study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer.http://www.sciencedirect.com/science/article/pii/S2452199X23001135Metal-organic frameworkTitanium-based nanomaterialsMicrowave dynamic therapyMicrowave thermal therapyMR image |
| spellingShingle | Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer Bioactive Materials Metal-organic framework Titanium-based nanomaterials Microwave dynamic therapy Microwave thermal therapy MR image |
| title | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| title_full | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| title_fullStr | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| title_full_unstemmed | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| title_short | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| title_sort | mn doped ti based mofs for magnetic resonance imaging guided synergistic microwave thermal and microwave dynamic therapy of liver cancer |
| topic | Metal-organic framework Titanium-based nanomaterials Microwave dynamic therapy Microwave thermal therapy MR image |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23001135 |
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