Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer
Abstract Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clinical characteristics of 881,320 patients recorded by the Surveillance, Epidemiology...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16749-4 |
| _version_ | 1811342728584232960 |
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| author | Yara Abdou Medhavi Gupta Mariko Asaoka Kristopher Attwood Opyrchal Mateusz Shipra Gandhi Kazuaki Takabe |
| author_facet | Yara Abdou Medhavi Gupta Mariko Asaoka Kristopher Attwood Opyrchal Mateusz Shipra Gandhi Kazuaki Takabe |
| author_sort | Yara Abdou |
| collection | DOAJ |
| description | Abstract Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clinical characteristics of 881,320 patients recorded by the Surveillance, Epidemiology, and End Results (SEER) program. The Cancer Genome Atlas (TCGA) was used to explore genomic and clinical features from 1,062 patients. Gene expression data was used to quantitate cytolytic activity and hallmark gene-sets were used for gene set enrichment analysis. An institutional retrospective review was conducted on 155 patients treated with neoadjuvant chemotherapy (NACT). Patient characteristics were summarized by pathological complete response (pCR). Left sided tumors were found to be more prevalent than right sided tumors. No major clinicopathological differences were noted by laterality. Left sided breast cancer demonstrated poorer outcomes versus right sided tumors (HR 1.05, 95% CI 1.01–1.08; p = 0.011). Cell proliferation gene sets, including E2F Targets, G2M Checkpoint, Mitotic spindle, and MYC Targets, were enriched on the left side compared to the right. Left sided tumors had lower pCR rates versus right sided tumors (15.4% versus 29.9%, p = 0.036). Our findings suggest that left sided breast cancer is associated with aggressive biology and worse outcomes compared to right sided breast cancer. |
| first_indexed | 2024-04-13T19:15:52Z |
| format | Article |
| id | doaj.art-b3eb4210066c4d778fbd0ef179581fe6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T19:15:52Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b3eb4210066c4d778fbd0ef179581fe62022-12-22T02:33:40ZengNature PortfolioScientific Reports2045-23222022-08-011211910.1038/s41598-022-16749-4Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancerYara Abdou0Medhavi Gupta1Mariko Asaoka2Kristopher Attwood3Opyrchal Mateusz4Shipra Gandhi5Kazuaki Takabe6Department of Medical Oncology, University of North CarolinaWarren Alpert School of Medicine, Brown University, Women & Infants HospitalDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer CenterDivision of Medical Oncology, Department of Statistics, Roswell Park Comprehensive Cancer CenterDivision of Medical Oncology, Washington University School of MedicineDivision of Medical Oncology, Roswell Park Comprehensive Cancer CenterDepartment of Surgical Oncology, Roswell Park Comprehensive Cancer CenterAbstract Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clinical characteristics of 881,320 patients recorded by the Surveillance, Epidemiology, and End Results (SEER) program. The Cancer Genome Atlas (TCGA) was used to explore genomic and clinical features from 1,062 patients. Gene expression data was used to quantitate cytolytic activity and hallmark gene-sets were used for gene set enrichment analysis. An institutional retrospective review was conducted on 155 patients treated with neoadjuvant chemotherapy (NACT). Patient characteristics were summarized by pathological complete response (pCR). Left sided tumors were found to be more prevalent than right sided tumors. No major clinicopathological differences were noted by laterality. Left sided breast cancer demonstrated poorer outcomes versus right sided tumors (HR 1.05, 95% CI 1.01–1.08; p = 0.011). Cell proliferation gene sets, including E2F Targets, G2M Checkpoint, Mitotic spindle, and MYC Targets, were enriched on the left side compared to the right. Left sided tumors had lower pCR rates versus right sided tumors (15.4% versus 29.9%, p = 0.036). Our findings suggest that left sided breast cancer is associated with aggressive biology and worse outcomes compared to right sided breast cancer.https://doi.org/10.1038/s41598-022-16749-4 |
| spellingShingle | Yara Abdou Medhavi Gupta Mariko Asaoka Kristopher Attwood Opyrchal Mateusz Shipra Gandhi Kazuaki Takabe Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer Scientific Reports |
| title | Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| title_full | Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| title_fullStr | Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| title_full_unstemmed | Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| title_short | Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| title_sort | left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer |
| url | https://doi.org/10.1038/s41598-022-16749-4 |
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