Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness
ObjectiveTo investigate the effects of cortical thickness on the identification accuracy of fractional amplitude of low-frequency fluctuation (fALFF) in patients with multiple sclerosis (MS).MethodsResting-state functional magnetic resonance imaging data were collected from 31 remitting MS, 20 acute...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1143646/full |
| _version_ | 1797674083721150464 |
|---|---|
| author | Xiao Liang Lei Wang Yanyan Zhu Yao Wang Ting He Lin Wu Muhua Huang Fuqing Zhou Fuqing Zhou |
| author_facet | Xiao Liang Lei Wang Yanyan Zhu Yao Wang Ting He Lin Wu Muhua Huang Fuqing Zhou Fuqing Zhou |
| author_sort | Xiao Liang |
| collection | DOAJ |
| description | ObjectiveTo investigate the effects of cortical thickness on the identification accuracy of fractional amplitude of low-frequency fluctuation (fALFF) in patients with multiple sclerosis (MS).MethodsResting-state functional magnetic resonance imaging data were collected from 31 remitting MS, 20 acute MS, and 42 healthy controls (HCs). After preprocessing, we first calculated two-dimensional fALFF (2d-fALFF) maps using the DPABISurf toolkit, and 2d-fALFF per unit thickness was obtained by dividing 2d-fALFF by cortical thickness. Then, between-group comparison, clinical correlation, and classification analyses were performed in 2d-fALFF and 2d-fALFF per unit thickness maps. Finally, we also examined whether the effect of cortical thickness on 2d-fALFF maps was affected by the subfrequency band.ResultsIn contrast with 2d-fALFF, more changed regions in 2d-fALFF per unit thickness maps were detected in MS patients, such as increased region of the right inferior frontal cortex and faded regions of the right paracentral lobule, middle cingulate cortex, and right medial temporal cortex. There was a significant positive correlation between the disease duration and the 2d-fALFF values in the left early visual cortex in remitting MS patients (r = 0.517, Bonferroni-corrected, p = 0.008 × 4 < 0.05). In contrast with 2d-fALFF, we detected a positive correlation between the 2d-fALFF per unit thickness of the right ventral stream visual cortex and the modified Fatigue Impact Scale (MFIS) scores (r = 0.555, Bonferroni-corrected, p = 0.017 × 4 > 0.05). For detecting MS patients, 2d-fALFF and 2d- fALFF per unit thickness both performed remarkably well in support vector machine (SVM) analysis, especially in the remitting phase (AUC = 86, 83%). Compared with 2d-fALFF, the SVM model of 2d-fALFF per unit thickness had significantly higher classification performance in distinguishing between remitting and acute MS. More changed regions and more clinically relevant 2d-fALFF per unit thickness maps in the subfrequency band were also detected in MS patients.ConclusionBy dividing the functional value by the cortical thickness, the identification accuracy of fALFF in MS patients was detected to be potentially influenced by cortical thickness. Additionally, 2d-fALFF per unit thickness is a potential diagnostic marker that can be utilized to distinguish between acute and remitting MS patients. Notably, we observed similar variations in the subfrequency band. |
| first_indexed | 2024-03-11T21:54:59Z |
| format | Article |
| id | doaj.art-b3ebacb4de264e569fbfec8c01848d9e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T21:54:59Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b3ebacb4de264e569fbfec8c01848d9e2023-09-26T04:43:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-09-011410.3389/fneur.2023.11436461143646Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thicknessXiao Liang0Lei Wang1Yanyan Zhu2Yao Wang3Ting He4Lin Wu5Muhua Huang6Fuqing Zhou7Fuqing Zhou8Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaInstitute of Medical Imaging, Nanchang University, Nanchang, Jiangxi, ChinaObjectiveTo investigate the effects of cortical thickness on the identification accuracy of fractional amplitude of low-frequency fluctuation (fALFF) in patients with multiple sclerosis (MS).MethodsResting-state functional magnetic resonance imaging data were collected from 31 remitting MS, 20 acute MS, and 42 healthy controls (HCs). After preprocessing, we first calculated two-dimensional fALFF (2d-fALFF) maps using the DPABISurf toolkit, and 2d-fALFF per unit thickness was obtained by dividing 2d-fALFF by cortical thickness. Then, between-group comparison, clinical correlation, and classification analyses were performed in 2d-fALFF and 2d-fALFF per unit thickness maps. Finally, we also examined whether the effect of cortical thickness on 2d-fALFF maps was affected by the subfrequency band.ResultsIn contrast with 2d-fALFF, more changed regions in 2d-fALFF per unit thickness maps were detected in MS patients, such as increased region of the right inferior frontal cortex and faded regions of the right paracentral lobule, middle cingulate cortex, and right medial temporal cortex. There was a significant positive correlation between the disease duration and the 2d-fALFF values in the left early visual cortex in remitting MS patients (r = 0.517, Bonferroni-corrected, p = 0.008 × 4 < 0.05). In contrast with 2d-fALFF, we detected a positive correlation between the 2d-fALFF per unit thickness of the right ventral stream visual cortex and the modified Fatigue Impact Scale (MFIS) scores (r = 0.555, Bonferroni-corrected, p = 0.017 × 4 > 0.05). For detecting MS patients, 2d-fALFF and 2d- fALFF per unit thickness both performed remarkably well in support vector machine (SVM) analysis, especially in the remitting phase (AUC = 86, 83%). Compared with 2d-fALFF, the SVM model of 2d-fALFF per unit thickness had significantly higher classification performance in distinguishing between remitting and acute MS. More changed regions and more clinically relevant 2d-fALFF per unit thickness maps in the subfrequency band were also detected in MS patients.ConclusionBy dividing the functional value by the cortical thickness, the identification accuracy of fALFF in MS patients was detected to be potentially influenced by cortical thickness. Additionally, 2d-fALFF per unit thickness is a potential diagnostic marker that can be utilized to distinguish between acute and remitting MS patients. Notably, we observed similar variations in the subfrequency band.https://www.frontiersin.org/articles/10.3389/fneur.2023.1143646/fullmultiple sclerosisfMRItwo-dimensional fALFFcortical thicknessmachine learning |
| spellingShingle | Xiao Liang Lei Wang Yanyan Zhu Yao Wang Ting He Lin Wu Muhua Huang Fuqing Zhou Fuqing Zhou Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness Frontiers in Neurology multiple sclerosis fMRI two-dimensional fALFF cortical thickness machine learning |
| title | Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness |
| title_full | Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness |
| title_fullStr | Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness |
| title_full_unstemmed | Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness |
| title_short | Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness |
| title_sort | altered neural intrinsic oscillations in patients with multiple sclerosis effects of cortical thickness |
| topic | multiple sclerosis fMRI two-dimensional fALFF cortical thickness machine learning |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1143646/full |
| work_keys_str_mv | AT xiaoliang alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT leiwang alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT yanyanzhu alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT yaowang alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT tinghe alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT linwu alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT muhuahuang alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT fuqingzhou alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness AT fuqingzhou alteredneuralintrinsicoscillationsinpatientswithmultiplesclerosiseffectsofcorticalthickness |