Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium

Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium

Polychlorinated biphenyls (PCBs) are putative environmental risks for neurodevelopmental disorders. Here, we tested two hypotheses: (1) developmental exposure to a human-relevant PCB mixture causes behavioral phenotypes relevant to neurodevelopmental disorders; and (2) expression of human mutations...

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Bibliographic Details
Main Authors: Sunjay Sethi, Kimberly P. Keil Stietz, Anthony E. Valenzuela, Carolyn R. Klocke, Jill L. Silverman, Birgit Puschner, Isaac N. Pessah, Pamela J. Lein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Neuroscience
Subjects:
FMR1 permutation
gene-environment interaction
neurodevelopmental disorders
ryanodine receptor
sex differences
social behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.766826/full

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