Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids

Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids

Liver is the primary acting site of insulin. In this study, we developed innovative nanoparticles for oral and liver-targeted delivery of insulin by using enterohepatic circulation of bile acids. The nanoparticles were produced from cholic acid and quaternary ammonium modified chitosan derivative an...

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Bibliographic Details
Main Authors:	Zhe Zhang, Hongxiang Li, Guangrui Xu, Ping Yao
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Series:	Drug Delivery
Subjects:	bile acid transporters chitosan derivative hpmcp insulin oral delivery
Online Access:	http://dx.doi.org/10.1080/10717544.2018.1469685

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