HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma
Abstract Background Accompanied by HBV infection, HBV mutations gradually occur because HBV polymerase appears proofread deficiencies. In our previous study, we have identified that EnhII/BCP/PC mutations and genotype C of HBV DNA were associated with hepatocellular carcinoma (HCC) risk. In this stu...
| Main Authors: | , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
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Wiley
2019-06-01
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| 叢編: | Cancer Medicine |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1002/cam4.2169 |
| _version_ | 1828852974770716672 |
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| author | Zijun Ge Ting Tian Lijuan Meng Ci Song Chengxiao Yu Xin Xu Jibin Liu Juncheng Dai Zhibin Hu |
| author_facet | Zijun Ge Ting Tian Lijuan Meng Ci Song Chengxiao Yu Xin Xu Jibin Liu Juncheng Dai Zhibin Hu |
| author_sort | Zijun Ge |
| collection | DOAJ |
| description | Abstract Background Accompanied by HBV infection, HBV mutations gradually occur because HBV polymerase appears proofread deficiencies. In our previous study, we have identified that EnhII/BCP/PC mutations and genotype C of HBV DNA were associated with hepatocellular carcinoma (HCC) risk. In this study, we extend our research to explore HCC prognosis associated genotype and mutations in EnhII/BCP/PC regions. Methods We designed a case‐cohort study of 331 HCC patients to evaluate the effects of the HBV genotypes and mutations on HCC survival. Log‐rank test and Cox proportional hazard models were used for the analyses. Results Results showed that genotype C, which was more frequent in HBV‐related HCC (77.4%), presented a negative signal with HCC survival. Interestingly, we detected a significant association between EnhII/BCP/PC mutation nt1753 and HCC prognosis (Log‐rank P = 0.034). Subgroup analysis revealed that this risk effect was more pronounced in non‐B genotype (P = 0.090 for heterogeneity test). We also detected a borderline multiplicative interaction between genotypes of nt1753 and HBV genotype on HCC survival (P for interaction = 0.069). Conclusions These findings indicated that, in Chinese population, nt1753 in EnhII/BCP/PC region might be a novel marker for HCC prognosis. |
| first_indexed | 2024-12-13T00:04:36Z |
| format | Article |
| id | doaj.art-b3f1366bb2d44bbd92f4ab199d25e06c |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-13T00:04:36Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-b3f1366bb2d44bbd92f4ab199d25e06c2022-12-22T00:06:18ZengWileyCancer Medicine2045-76342019-06-01863086309310.1002/cam4.2169HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinomaZijun Ge0Ting Tian1Lijuan Meng2Ci Song3Chengxiao Yu4Xin Xu5Jibin Liu6Juncheng Dai7Zhibin Hu8State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaIntegrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaDepartment of Hepatobiliary Surgery Nantong Tumor Hospital Nantong ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaState Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing ChinaAbstract Background Accompanied by HBV infection, HBV mutations gradually occur because HBV polymerase appears proofread deficiencies. In our previous study, we have identified that EnhII/BCP/PC mutations and genotype C of HBV DNA were associated with hepatocellular carcinoma (HCC) risk. In this study, we extend our research to explore HCC prognosis associated genotype and mutations in EnhII/BCP/PC regions. Methods We designed a case‐cohort study of 331 HCC patients to evaluate the effects of the HBV genotypes and mutations on HCC survival. Log‐rank test and Cox proportional hazard models were used for the analyses. Results Results showed that genotype C, which was more frequent in HBV‐related HCC (77.4%), presented a negative signal with HCC survival. Interestingly, we detected a significant association between EnhII/BCP/PC mutation nt1753 and HCC prognosis (Log‐rank P = 0.034). Subgroup analysis revealed that this risk effect was more pronounced in non‐B genotype (P = 0.090 for heterogeneity test). We also detected a borderline multiplicative interaction between genotypes of nt1753 and HBV genotype on HCC survival (P for interaction = 0.069). Conclusions These findings indicated that, in Chinese population, nt1753 in EnhII/BCP/PC region might be a novel marker for HCC prognosis.https://doi.org/10.1002/cam4.2169HBV genotypeHBV mutationHCC |
| spellingShingle | Zijun Ge Ting Tian Lijuan Meng Ci Song Chengxiao Yu Xin Xu Jibin Liu Juncheng Dai Zhibin Hu HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma Cancer Medicine HBV genotype HBV mutation HCC |
| title | HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma |
| title_full | HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma |
| title_fullStr | HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma |
| title_full_unstemmed | HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma |
| title_short | HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma |
| title_sort | hbv mutations in enhii bcp pc region contribute to the prognosis of hepatocellular carcinoma |
| topic | HBV genotype HBV mutation HCC |
| url | https://doi.org/10.1002/cam4.2169 |
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