Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report
Toxoplasmosis is caused by infection with the obligate intracellular parasite Toxoplasma gondii. Toxoplasmosis is generally a late complication of HIV infection and usually occurs in patients with CD4 + T-cell counts below 200/μl. Co-trimoxazole (trimethoprim plus sulfamethoxazole) is the most commo...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2012-09-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=292&type=fultext |
| _version_ | 1819037309142564864 |
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| author | Deepak Madi Basavaprabhu Achappa Satish Rao John T. Ramapuram Soundarya Mahalingam |
| author_facet | Deepak Madi Basavaprabhu Achappa Satish Rao John T. Ramapuram Soundarya Mahalingam |
| author_sort | Deepak Madi |
| collection | DOAJ |
| description | Toxoplasmosis is caused by infection with the obligate intracellular parasite Toxoplasma gondii. Toxoplasmosis is generally a late complication of HIV infection and usually occurs in patients with CD4 + T-cell counts below 200/μl. Co-trimoxazole (trimethoprim plus sulfamethoxazole) is the most common drug used in India for the treatment of AIDS-associated cerebral toxoplasmosis. Other alternative drugs used for the treatment of cerebral toxoplasmosis are clindamycin plus pyrimethamine and clarithromycin with pyrimethamine.A 30-year-old male known case of retroviral disease presented to Kasturba Medical College, India, with complaints of fever, headache and vomiting. Computed tomography scan of his brain showed irregular ring enhancing lesion in the right basal ganglia. Toxoplasma serology revealed raised IgG antibody levels. Based on the CT features and serology, diagnosis of cerebral toxoplasmosis was made. He was treated with clindamycin alone as he had historyof sulfonamide allergy. The patient was symptomatically better after 48 hours. After 21 days, repeat CT of brain was done which was normal. The patient showed good clinical improvement within 48 hours and the lesion resolved completely within 3 weeks. The authors recommend using clindamycin without pyrimethamine in resource poor settings and in patients who do not tolerate sulfa drugs. |
| first_indexed | 2024-12-21T08:19:22Z |
| format | Article |
| id | doaj.art-b3f26ffa290c40fc8ea72a7e81cb1390 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-21T08:19:22Z |
| publishDate | 2012-09-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-b3f26ffa290c40fc8ea72a7e81cb13902022-12-21T19:10:28ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042012-09-01275411412Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case ReportDeepak MadiBasavaprabhu AchappaSatish RaoJohn T. RamapuramSoundarya MahalingamToxoplasmosis is caused by infection with the obligate intracellular parasite Toxoplasma gondii. Toxoplasmosis is generally a late complication of HIV infection and usually occurs in patients with CD4 + T-cell counts below 200/μl. Co-trimoxazole (trimethoprim plus sulfamethoxazole) is the most common drug used in India for the treatment of AIDS-associated cerebral toxoplasmosis. Other alternative drugs used for the treatment of cerebral toxoplasmosis are clindamycin plus pyrimethamine and clarithromycin with pyrimethamine.A 30-year-old male known case of retroviral disease presented to Kasturba Medical College, India, with complaints of fever, headache and vomiting. Computed tomography scan of his brain showed irregular ring enhancing lesion in the right basal ganglia. Toxoplasma serology revealed raised IgG antibody levels. Based on the CT features and serology, diagnosis of cerebral toxoplasmosis was made. He was treated with clindamycin alone as he had historyof sulfonamide allergy. The patient was symptomatically better after 48 hours. After 21 days, repeat CT of brain was done which was normal. The patient showed good clinical improvement within 48 hours and the lesion resolved completely within 3 weeks. The authors recommend using clindamycin without pyrimethamine in resource poor settings and in patients who do not tolerate sulfa drugs.http://www.omjournal.org/fultext_PDF.aspx?DetailsID=292&type=fultextCerebral toxoplasmosisClindamycinHIV/AIDS. |
| spellingShingle | Deepak Madi Basavaprabhu Achappa Satish Rao John T. Ramapuram Soundarya Mahalingam Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report Oman Medical Journal Cerebral toxoplasmosis Clindamycin HIV/AIDS. |
| title | Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report |
| title_full | Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report |
| title_fullStr | Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report |
| title_full_unstemmed | Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report |
| title_short | Successful Treatment of Cerebral Toxoplasmosis with Clindamycin: A Case Report |
| title_sort | successful treatment of cerebral toxoplasmosis with clindamycin a case report |
| topic | Cerebral toxoplasmosis Clindamycin HIV/AIDS. |
| url | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=292&type=fultext |
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