Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor
Margaret M Marczewski1, Marek Postula1,2, Dariusz Kosior111st Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw, Warsaw, Poland; 2Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, PolandAbstract: Atherothrombosis,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-05-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/novel-antiplatelet-agents-in-the-prevention-of-cardiovascular-complica-a4499 |
| _version_ | 1818235549166600192 |
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| author | Margaret M Marczewski Marek Postula Dariusz Kosior |
| author_facet | Margaret M Marczewski Marek Postula Dariusz Kosior |
| author_sort | Margaret M Marczewski |
| collection | DOAJ |
| description | Margaret M Marczewski1, Marek Postula1,2, Dariusz Kosior111st Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw, Warsaw, Poland; 2Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, PolandAbstract: Atherothrombosis, thrombus formation as a result of atherosclerotic plaque rupture, is a major modern health problem, often underlying coronary artery disease, stroke, and peripheral arterial disease. After the treatment of an acute thrombotic episode, long-term therapy is warranted as a secondary prophylaxis of such events and their complications. Because of the importance of platelets’ involvement in the initiation and propagation of thrombosis, antiplatelet drugs have come to the forefront of atherothrombotic disease treatment. Dual antiplatelet therapy of aspirin plus clopidogrel – the current standard – has its benefits, but it also has its limitations with regard to its pharmacologic properties and adverse effects. For these reasons, within the last decade or so, the investigation of novel antiplatelet agents has prospered. Here, we review the main pathways through which platelets participate in acute thrombosis and the interruption of these pathways by using novel antiplatelet agents, including P2Y12 receptor antagonists (the recently approved prasugrel, the probable next-in-line ticagrelor, and others). The need for a more individualized patient therapy is evident; although most of the aforementioned pharmaceuticals have the potential to contribute to this, their clinical utility remains to be seen.Keywords: antiplatelet therapy, antagonist, P2Y12 receptor, ADP receptor |
| first_indexed | 2024-12-12T11:55:44Z |
| format | Article |
| id | doaj.art-b3f2bf856e9b439d890c1848d3045a70 |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T11:55:44Z |
| publishDate | 2010-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-b3f2bf856e9b439d890c1848d3045a702022-12-22T00:25:12ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482010-05-012010default419429Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelorMargaret M MarczewskiMarek PostulaDariusz KosiorMargaret M Marczewski1, Marek Postula1,2, Dariusz Kosior111st Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw, Warsaw, Poland; 2Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, PolandAbstract: Atherothrombosis, thrombus formation as a result of atherosclerotic plaque rupture, is a major modern health problem, often underlying coronary artery disease, stroke, and peripheral arterial disease. After the treatment of an acute thrombotic episode, long-term therapy is warranted as a secondary prophylaxis of such events and their complications. Because of the importance of platelets’ involvement in the initiation and propagation of thrombosis, antiplatelet drugs have come to the forefront of atherothrombotic disease treatment. Dual antiplatelet therapy of aspirin plus clopidogrel – the current standard – has its benefits, but it also has its limitations with regard to its pharmacologic properties and adverse effects. For these reasons, within the last decade or so, the investigation of novel antiplatelet agents has prospered. Here, we review the main pathways through which platelets participate in acute thrombosis and the interruption of these pathways by using novel antiplatelet agents, including P2Y12 receptor antagonists (the recently approved prasugrel, the probable next-in-line ticagrelor, and others). The need for a more individualized patient therapy is evident; although most of the aforementioned pharmaceuticals have the potential to contribute to this, their clinical utility remains to be seen.Keywords: antiplatelet therapy, antagonist, P2Y12 receptor, ADP receptorhttp://www.dovepress.com/novel-antiplatelet-agents-in-the-prevention-of-cardiovascular-complica-a4499 |
| spellingShingle | Margaret M Marczewski Marek Postula Dariusz Kosior Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor Vascular Health and Risk Management |
| title | Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor |
| title_full | Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor |
| title_fullStr | Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor |
| title_full_unstemmed | Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor |
| title_short | Novel antiplatelet agents in the prevention of cardiovascular complications – focus on ticagrelor |
| title_sort | novel antiplatelet agents in the prevention of cardiovascular complications amp ndash focus on ticagrelor |
| url | http://www.dovepress.com/novel-antiplatelet-agents-in-the-prevention-of-cardiovascular-complica-a4499 |
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