SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model

SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model

Summary: Background: Type I IFN (IFN-I) is a family of cytokines involved in the pathogenesis of autoimmune and autoinflammatory diseases such as psoriasis. SIDT1 is an ER-resident protein expressed in the lymphoid lineage, and involved in anti-viral IFN-I responses in vivo, through an unclear mech...

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Bibliographic Details
Main Authors: María Morell, Nieves Varela, Casimiro Castillejo-López, Céline Coppard, María José Luque, Ying-Yu Wu, Natividad Martín-Morales, Francisco Pérez-Cózar, Gonzalo Gómez-Hernández, Ramesh Kumar, Francisco O'Valle, Marta E. Alarcón-Riquelme, Concepción Marañón
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:EBioMedicine
Subjects:
SIDT1
pDC
IFN-I
Proinflammatory cytokines
TLR7
TLR9
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421006022

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