A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode
Background: Pulmonary vein (PV) reconnection is the major cause of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). The probability of reconnection is higher if the primary lesion is not sufficiently effective, which can be unmasked with an adenosine provocation test (APT)....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/3/98 |
| _version_ | 1827749385231925248 |
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| author | Sönke Schildt Sabine Fredersdorf Carsten G. Jungbauer Christian Hauck Daniel Tarnowski Kurt Debl Stefan Neef Christian Schach Samuel Sossalla Lars S. Maier Ekrem Üçer |
| author_facet | Sönke Schildt Sabine Fredersdorf Carsten G. Jungbauer Christian Hauck Daniel Tarnowski Kurt Debl Stefan Neef Christian Schach Samuel Sossalla Lars S. Maier Ekrem Üçer |
| author_sort | Sönke Schildt |
| collection | DOAJ |
| description | Background: Pulmonary vein (PV) reconnection is the major cause of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). The probability of reconnection is higher if the primary lesion is not sufficiently effective, which can be unmasked with an adenosine provocation test (APT). High-power short-duration radiofrequency energy (HPSD) guided with ablation index (AI) and the third generation of the visually guided laser balloon (VGLB) are new methods for PVI. Methods: A total of 70 participants (35 in each group) who underwent a PVI with either AI-guided HPSD (50 W; AI 500 for the anterior and 400 for the posterior wall, respectively) or VGLB ablation were included in this observational pilot trial. Twenty minutes after each PVI, an APT was performed. The primary endpoint was the event-free survival from AF after three years. Results: A total of 137 (100%) PVs in the HPSD arm and 131 PVs (98.5%) in the VGLB arm were initially successfully isolated (<i>p</i> = 0.24). The overall procedure duration was similar in both arms (155 ± 39 in HPSD vs. 175 ± 58 min in VGLB, <i>p</i> = 0.191). Fluoroscopy time, left atrial dwelling time and duration from the first to the last ablation were longer in the VGLB arm (23 ± 8 vs. 12 ± 3 min, <i>p</i> < 0.001; 157 (111–185) vs. 134 (104–154) min, <i>p</i> = 0.049; 92(59–108) vs. 72 (43–85) min, <i>p</i> = 0.010). A total of 127 (93%) in the HPSD arm and 126 (95%) PVs in the VGLB arm remained isolated after APT (<i>p</i> = 0.34). The primary endpoint was met 1107 ± 68 days after ablation in 71% vs. 66% in the VGLB and HPSD arms, respectively (<i>p</i> = 0.65). Conclusions: HPSD and VGLB did not differ with respect to long-term outcome of PVI. A large, randomized study should be conducted to compare clinical outcomes with respect to these new ablation techniques. |
| first_indexed | 2024-03-11T06:23:20Z |
| format | Article |
| id | doaj.art-b3fa10b07ff847f6aed88097abd2545d |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T06:23:20Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-b3fa10b07ff847f6aed88097abd2545d2023-11-17T11:47:23ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-02-011039810.3390/jcdd10030098A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation ModeSönke Schildt0Sabine Fredersdorf1Carsten G. Jungbauer2Christian Hauck3Daniel Tarnowski4Kurt Debl5Stefan Neef6Christian Schach7Samuel Sossalla8Lars S. Maier9Ekrem Üçer10Internal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyInternal Medicine II, Cardiology, University Hospital Regensburg, 93053 Regensburg, GermanyBackground: Pulmonary vein (PV) reconnection is the major cause of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). The probability of reconnection is higher if the primary lesion is not sufficiently effective, which can be unmasked with an adenosine provocation test (APT). High-power short-duration radiofrequency energy (HPSD) guided with ablation index (AI) and the third generation of the visually guided laser balloon (VGLB) are new methods for PVI. Methods: A total of 70 participants (35 in each group) who underwent a PVI with either AI-guided HPSD (50 W; AI 500 for the anterior and 400 for the posterior wall, respectively) or VGLB ablation were included in this observational pilot trial. Twenty minutes after each PVI, an APT was performed. The primary endpoint was the event-free survival from AF after three years. Results: A total of 137 (100%) PVs in the HPSD arm and 131 PVs (98.5%) in the VGLB arm were initially successfully isolated (<i>p</i> = 0.24). The overall procedure duration was similar in both arms (155 ± 39 in HPSD vs. 175 ± 58 min in VGLB, <i>p</i> = 0.191). Fluoroscopy time, left atrial dwelling time and duration from the first to the last ablation were longer in the VGLB arm (23 ± 8 vs. 12 ± 3 min, <i>p</i> < 0.001; 157 (111–185) vs. 134 (104–154) min, <i>p</i> = 0.049; 92(59–108) vs. 72 (43–85) min, <i>p</i> = 0.010). A total of 127 (93%) in the HPSD arm and 126 (95%) PVs in the VGLB arm remained isolated after APT (<i>p</i> = 0.34). The primary endpoint was met 1107 ± 68 days after ablation in 71% vs. 66% in the VGLB and HPSD arms, respectively (<i>p</i> = 0.65). Conclusions: HPSD and VGLB did not differ with respect to long-term outcome of PVI. A large, randomized study should be conducted to compare clinical outcomes with respect to these new ablation techniques.https://www.mdpi.com/2308-3425/10/3/98atrial fibrillationpulmonary vein isolationhigh-power short-durationlaser balloonadenosine |
| spellingShingle | Sönke Schildt Sabine Fredersdorf Carsten G. Jungbauer Christian Hauck Daniel Tarnowski Kurt Debl Stefan Neef Christian Schach Samuel Sossalla Lars S. Maier Ekrem Üçer A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode Journal of Cardiovascular Development and Disease atrial fibrillation pulmonary vein isolation high-power short-duration laser balloon adenosine |
| title | A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode |
| title_full | A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode |
| title_fullStr | A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode |
| title_full_unstemmed | A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode |
| title_short | A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode |
| title_sort | pilot trial to compare the long term efficacy of pulmonary vein isolation with high power short duration radiofrequency versus laser energy with rapid ablation mode |
| topic | atrial fibrillation pulmonary vein isolation high-power short-duration laser balloon adenosine |
| url | https://www.mdpi.com/2308-3425/10/3/98 |
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