<i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity
<i>Maytenus macrocarpa</i> (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpene...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/12/2288 |
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| author | Milan Malaník Jakub Treml Veronika Rjašková Karolina Tížková Petra Kaucká Ladislav Kokoška Peter Kubatka Karel Šmejkal |
| author_facet | Milan Malaník Jakub Treml Veronika Rjašková Karolina Tížková Petra Kaucká Ladislav Kokoška Peter Kubatka Karel Šmejkal |
| author_sort | Milan Malaník |
| collection | DOAJ |
| description | <i>Maytenus macrocarpa</i> (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpenes and dihydro-β-agarofuran sesquiterpenes were isolated from <i>M. macrocarpa</i>. Extracts and selected pure compounds isolated from the leaves, roots, and stem bark showed antibacterial, antiviral, antiparasitic, anti-inflammatory, and cytotoxic activities in vitro. The aim of this review is to summarize the available ethnobotanical, phytochemical, and pharmacological information about this traditional Amazonian medicinal tree, as well as to attract the attention of phytochemists and pharmacognosists to this potentially interesting source of ethnopharmaceuticals. |
| first_indexed | 2024-12-20T18:55:51Z |
| format | Article |
| id | doaj.art-b3fac71d8a4f4d75a0ad504680f48850 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T18:55:51Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b3fac71d8a4f4d75a0ad504680f488502022-12-21T19:29:31ZengMDPI AGMolecules1420-30492019-06-012412228810.3390/molecules24122288molecules24122288<i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological ActivityMilan Malaník0Jakub Treml1Veronika Rjašková2Karolina Tížková3Petra Kaucká4Ladislav Kokoška5Peter Kubatka6Karel Šmejkal7Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech RepublicDepartment of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech RepublicDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech RepublicDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech RepublicDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech RepublicDepartment of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamýcká 129, 16500 Praha-Suchdol, Czech RepublicDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, SlovakiaDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1, 61242 Brno, Czech Republic<i>Maytenus macrocarpa</i> (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpenes and dihydro-β-agarofuran sesquiterpenes were isolated from <i>M. macrocarpa</i>. Extracts and selected pure compounds isolated from the leaves, roots, and stem bark showed antibacterial, antiviral, antiparasitic, anti-inflammatory, and cytotoxic activities in vitro. The aim of this review is to summarize the available ethnobotanical, phytochemical, and pharmacological information about this traditional Amazonian medicinal tree, as well as to attract the attention of phytochemists and pharmacognosists to this potentially interesting source of ethnopharmaceuticals.https://www.mdpi.com/1420-3049/24/12/2288dihydro-β-agarofuran sesquiterpenefolk medicine<i>Maytenus macrocarpa</i>rheumatismtriterpene |
| spellingShingle | Milan Malaník Jakub Treml Veronika Rjašková Karolina Tížková Petra Kaucká Ladislav Kokoška Peter Kubatka Karel Šmejkal <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity Molecules dihydro-β-agarofuran sesquiterpene folk medicine <i>Maytenus macrocarpa</i> rheumatism triterpene |
| title | <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity |
| title_full | <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity |
| title_fullStr | <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity |
| title_full_unstemmed | <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity |
| title_short | <i>Maytenus macrocarpa</i> (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity |
| title_sort | i maytenus macrocarpa i ruiz amp pav briq phytochemistry and pharmacological activity |
| topic | dihydro-β-agarofuran sesquiterpene folk medicine <i>Maytenus macrocarpa</i> rheumatism triterpene |
| url | https://www.mdpi.com/1420-3049/24/12/2288 |
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