Recent Advances in Electrochemical and Optical Sensing of Dopamine
Nowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/20/4/1039 |
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| author | Faten Bashar Kamal Eddin Yap Wing Fen |
| author_facet | Faten Bashar Kamal Eddin Yap Wing Fen |
| author_sort | Faten Bashar Kamal Eddin |
| collection | DOAJ |
| description | Nowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient’s life in addition to reducing the treatment cost. Therefore, the design and development of diagnostic tool for in vivo and in vitro monitoring of DA is of considerable clinical and pharmacological importance. In recent decades, a large number of techniques have been established for DA detection, including chromatography coupled to mass spectrometry, spectroscopic approaches, and electrochemical (EC) methods. These methods are effective, but most of them still have some drawbacks such as consuming time, effort, and money. Added to that, sometimes they need complex procedures to obtain good sensitivity and suffer from low selectivity due to interference from other biological species such as uric acid (UA) and ascorbic acid (AA). Advanced materials can offer remarkable opportunities to overcome drawbacks in conventional DA sensors. This review aims to explain challenges related to DA detection using different techniques, and to summarize and highlight recent advancements in materials used and approaches applied for several sensor surface modification for the monitoring of DA. Also, it focuses on the analytical features of the EC and optical-based sensing techniques available. |
| first_indexed | 2024-04-11T11:01:12Z |
| format | Article |
| id | doaj.art-b3fb103cbf264b2f89d96ddb76051289 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:01:12Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-b3fb103cbf264b2f89d96ddb760512892022-12-22T04:28:36ZengMDPI AGSensors1424-82202020-02-01204103910.3390/s20041039s20041039Recent Advances in Electrochemical and Optical Sensing of DopamineFaten Bashar Kamal Eddin0Yap Wing Fen1Department of Physics, Faculty of Science, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, MalaysiaDepartment of Physics, Faculty of Science, Universiti Putra Malaysia, Serdang 43400 UPM, Selangor, MalaysiaNowadays, several neurological disorders and neurocrine tumours are associated with dopamine (DA) concentrations in various biological fluids. Highly accurate and ultrasensitive detection of DA levels in different biological samples in real-time can change and improve the quality of a patient’s life in addition to reducing the treatment cost. Therefore, the design and development of diagnostic tool for in vivo and in vitro monitoring of DA is of considerable clinical and pharmacological importance. In recent decades, a large number of techniques have been established for DA detection, including chromatography coupled to mass spectrometry, spectroscopic approaches, and electrochemical (EC) methods. These methods are effective, but most of them still have some drawbacks such as consuming time, effort, and money. Added to that, sometimes they need complex procedures to obtain good sensitivity and suffer from low selectivity due to interference from other biological species such as uric acid (UA) and ascorbic acid (AA). Advanced materials can offer remarkable opportunities to overcome drawbacks in conventional DA sensors. This review aims to explain challenges related to DA detection using different techniques, and to summarize and highlight recent advancements in materials used and approaches applied for several sensor surface modification for the monitoring of DA. Also, it focuses on the analytical features of the EC and optical-based sensing techniques available.https://www.mdpi.com/1424-8220/20/4/1039nanomaterialselectrochemicalopticalsurface plasmon resonancesensorsdopamine |
| spellingShingle | Faten Bashar Kamal Eddin Yap Wing Fen Recent Advances in Electrochemical and Optical Sensing of Dopamine Sensors nanomaterials electrochemical optical surface plasmon resonance sensors dopamine |
| title | Recent Advances in Electrochemical and Optical Sensing of Dopamine |
| title_full | Recent Advances in Electrochemical and Optical Sensing of Dopamine |
| title_fullStr | Recent Advances in Electrochemical and Optical Sensing of Dopamine |
| title_full_unstemmed | Recent Advances in Electrochemical and Optical Sensing of Dopamine |
| title_short | Recent Advances in Electrochemical and Optical Sensing of Dopamine |
| title_sort | recent advances in electrochemical and optical sensing of dopamine |
| topic | nanomaterials electrochemical optical surface plasmon resonance sensors dopamine |
| url | https://www.mdpi.com/1424-8220/20/4/1039 |
| work_keys_str_mv | AT fatenbasharkamaleddin recentadvancesinelectrochemicalandopticalsensingofdopamine AT yapwingfen recentadvancesinelectrochemicalandopticalsensingofdopamine |