Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR
Observations have been made regarding the effects of long-term exercise training on blood pressure, renal sodium handling and renal renin–angiotensin–aldosterone (RAS) intracellular pathways in conscious, trained Okamoto–Aoki spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKy) normotensive...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2011-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320311408750 |
| _version_ | 1797282036859273216 |
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| author | Silmara Ciampone Rafael Borges Ize P de Lima Flávia F Mesquita Elizabeth C Cambiucci José AR Gontijo |
| author_facet | Silmara Ciampone Rafael Borges Ize P de Lima Flávia F Mesquita Elizabeth C Cambiucci José AR Gontijo |
| author_sort | Silmara Ciampone |
| collection | DOAJ |
| description | Observations have been made regarding the effects of long-term exercise training on blood pressure, renal sodium handling and renal renin–angiotensin–aldosterone (RAS) intracellular pathways in conscious, trained Okamoto–Aoki spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKy) normotensive rats, compared with appropriate age-matched sedentary SHR and WKy. To evaluate the influence of exercise training on renal function and RAS, receptors and intracellular angiotensin II (AngII) pathway compounds were used respectively, and lithium clearance and western blot methods were utilised. The current study demonstrated that increased blood pressure in SHR was blunted and significantly reduced by long-term swim training between the ages of 6 and 16 weeks. Additionally, the investigators observed an increased fractional urinary sodium excretion in trained SHR (SHR T ) rats, compared with sedentary SHR (SHR S ), despite a significantly decreased creatinine clearance (C Cr ). Furthermore, immunoblotting analysis demonstrated a decreased expression of AT1 R in the entire kidney of T SHR rats, compared with S SHR . Conversely, the expression of the AT2 R , in both sedentary and trained SHR, was unchanged. The present study may indicate that, in the kidney, long-term exercise exerts a modulating effect on AngII receptor expression. In fact, the present study indicates an association of increasing natriuresis, reciprocal changes in renal AngII receptors and intracellular pathway proteins with the fall in blood pressure levels observed in T SHR rats compared with age-matched S SHR rats. |
| first_indexed | 2024-03-07T17:07:07Z |
| format | Article |
| id | doaj.art-b3fcd8f1c8f948a5a3fe94086411af6f |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:07:07Z |
| publishDate | 2011-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-b3fcd8f1c8f948a5a3fe94086411af6f2024-03-03T02:33:11ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762011-12-011210.1177/1470320311408750Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHRSilmara CiamponeRafael BorgesIze P de LimaFlávia F MesquitaElizabeth C CambiucciJosé AR GontijoObservations have been made regarding the effects of long-term exercise training on blood pressure, renal sodium handling and renal renin–angiotensin–aldosterone (RAS) intracellular pathways in conscious, trained Okamoto–Aoki spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKy) normotensive rats, compared with appropriate age-matched sedentary SHR and WKy. To evaluate the influence of exercise training on renal function and RAS, receptors and intracellular angiotensin II (AngII) pathway compounds were used respectively, and lithium clearance and western blot methods were utilised. The current study demonstrated that increased blood pressure in SHR was blunted and significantly reduced by long-term swim training between the ages of 6 and 16 weeks. Additionally, the investigators observed an increased fractional urinary sodium excretion in trained SHR (SHR T ) rats, compared with sedentary SHR (SHR S ), despite a significantly decreased creatinine clearance (C Cr ). Furthermore, immunoblotting analysis demonstrated a decreased expression of AT1 R in the entire kidney of T SHR rats, compared with S SHR . Conversely, the expression of the AT2 R , in both sedentary and trained SHR, was unchanged. The present study may indicate that, in the kidney, long-term exercise exerts a modulating effect on AngII receptor expression. In fact, the present study indicates an association of increasing natriuresis, reciprocal changes in renal AngII receptors and intracellular pathway proteins with the fall in blood pressure levels observed in T SHR rats compared with age-matched S SHR rats.https://doi.org/10.1177/1470320311408750 |
| spellingShingle | Silmara Ciampone Rafael Borges Ize P de Lima Flávia F Mesquita Elizabeth C Cambiucci José AR Gontijo Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR Journal of the Renin-Angiotensin-Aldosterone System |
| title | Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR |
| title_full | Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR |
| title_fullStr | Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR |
| title_full_unstemmed | Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR |
| title_short | Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR |
| title_sort | long term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin ii signalling and urinary sodium excretion in shr |
| url | https://doi.org/10.1177/1470320311408750 |
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