N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat.

N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat.

Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopamine (NOD) activates TRPV1 and if it improves AKI. T...

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Main Authors: Charalambos Tsagogiorgas, Johannes Wedel, Maximilia Hottenrott, Michael O Schneider, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Bastian Theisinger, Sonja Theisinger, Rüdiger Waldherr, Bernhard K Krämer, Manfred Thiel, Peter Schnuelle, Benito A Yard, Simone Hoeger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3423369?pdf=render

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