miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.
More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3380909?pdf=render |
| _version_ | 1818151903111938048 |
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| author | Fei Lin Ran Li Zeng Xiang Pan Bo Zhou De Bing Yu Xu Guang Wang Xue Shan Ma Jing Han Ming Shen Hong Lin Liu |
| author_facet | Fei Lin Ran Li Zeng Xiang Pan Bo Zhou De Bing Yu Xu Guang Wang Xue Shan Ma Jing Han Ming Shen Hong Lin Liu |
| author_sort | Fei Lin |
| collection | DOAJ |
| description | More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro. |
| first_indexed | 2024-12-11T13:46:13Z |
| format | Article |
| id | doaj.art-b3fe2be766704fb38a79fc3145a518ba |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T13:46:13Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b3fe2be766704fb38a79fc3145a518ba2022-12-22T01:04:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3864010.1371/journal.pone.0038640miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.Fei LinRan LiZeng Xiang PanBo ZhouDe Bing YuXu Guang WangXue Shan MaJing HanMing ShenHong Lin LiuMore than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro.http://europepmc.org/articles/PMC3380909?pdf=render |
| spellingShingle | Fei Lin Ran Li Zeng Xiang Pan Bo Zhou De Bing Yu Xu Guang Wang Xue Shan Ma Jing Han Ming Shen Hong Lin Liu miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. PLoS ONE |
| title | miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. |
| title_full | miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. |
| title_fullStr | miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. |
| title_full_unstemmed | miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. |
| title_short | miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary. |
| title_sort | mir 26b promotes granulosa cell apoptosis by targeting atm during follicular atresia in porcine ovary |
| url | http://europepmc.org/articles/PMC3380909?pdf=render |
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