Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis
Background: Mandibular advancement devices for obstructive sleep apnea treatment are becoming increasingly popular among patients who do not prefer CPAP devices or surgery. Our study aims to evaluate the literature regarding potential dental and skeletal side effects caused by mandibular advancement...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/3/483 |
| _version_ | 1797446304868073472 |
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| author | Ioannis A. Tsolakis Juan Martin Palomo Stefanos Matthaios Apostolos I. Tsolakis |
| author_facet | Ioannis A. Tsolakis Juan Martin Palomo Stefanos Matthaios Apostolos I. Tsolakis |
| author_sort | Ioannis A. Tsolakis |
| collection | DOAJ |
| description | Background: Mandibular advancement devices for obstructive sleep apnea treatment are becoming increasingly popular among patients who do not prefer CPAP devices or surgery. Our study aims to evaluate the literature regarding potential dental and skeletal side effects caused by mandibular advancement appliances used for adult OSA treatment. Methods: Electronic databases were searched for published and unpublished literature along with the reference lists of the eligible studies. Randomized clinical trials and non-randomized trials assessing dental and skeletal changes by comparing cephalometric radiographs were selected. Study selection, data extraction, and risk of bias assessment were performed individually and in duplicate. Fourteen articles were finally selected (two randomized clinical trials and 12 non-randomized trials). Results: The results suggest that mandibular advancement devices used for OSA treatment increase the lower incisor proclination by 1.54 ± 0.16°, decrease overjet by 0.89 ± 0.04 mm and overbite by 0.68 ± 0.04 mm, rotate the mandible downward and forward, and increase the SNA angle by to 0.06 ± 0.03°. The meta-analysis revealed high statistical heterogeneity. Conclusions: The MADs affect the lower incisor proclination, overjet, overbite, the rotation of the mandible and the SNA angle. More randomized clinical trials providing high-quality evidence are needed to support those findings. |
| first_indexed | 2024-03-09T13:39:38Z |
| format | Article |
| id | doaj.art-b4005054774a45d286269eaa50400841 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T13:39:38Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-b4005054774a45d286269eaa504008412023-11-30T21:09:06ZengMDPI AGJournal of Personalized Medicine2075-44262022-03-0112348310.3390/jpm12030483Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-AnalysisIoannis A. Tsolakis0Juan Martin Palomo1Stefanos Matthaios2Apostolos I. Tsolakis3Department of Orthodontics, School of Dentistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreeceDepartment of Orthodontics, Case Western Reserve University School of Dental Medicine, Cleveland, OH 44106, USADepartment of Orthodontics, Case Western Reserve University School of Dental Medicine, Cleveland, OH 44106, USADepartment of Orthodontics, School of Dentistry, National and Kapodistrian, University of Athens, 157 72 Athens, GreeceBackground: Mandibular advancement devices for obstructive sleep apnea treatment are becoming increasingly popular among patients who do not prefer CPAP devices or surgery. Our study aims to evaluate the literature regarding potential dental and skeletal side effects caused by mandibular advancement appliances used for adult OSA treatment. Methods: Electronic databases were searched for published and unpublished literature along with the reference lists of the eligible studies. Randomized clinical trials and non-randomized trials assessing dental and skeletal changes by comparing cephalometric radiographs were selected. Study selection, data extraction, and risk of bias assessment were performed individually and in duplicate. Fourteen articles were finally selected (two randomized clinical trials and 12 non-randomized trials). Results: The results suggest that mandibular advancement devices used for OSA treatment increase the lower incisor proclination by 1.54 ± 0.16°, decrease overjet by 0.89 ± 0.04 mm and overbite by 0.68 ± 0.04 mm, rotate the mandible downward and forward, and increase the SNA angle by to 0.06 ± 0.03°. The meta-analysis revealed high statistical heterogeneity. Conclusions: The MADs affect the lower incisor proclination, overjet, overbite, the rotation of the mandible and the SNA angle. More randomized clinical trials providing high-quality evidence are needed to support those findings.https://www.mdpi.com/2075-4426/12/3/483mandibular advancement devices (MADs)obstructive sleep apnea (OSA)dental effectsskeletal effectsadults |
| spellingShingle | Ioannis A. Tsolakis Juan Martin Palomo Stefanos Matthaios Apostolos I. Tsolakis Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis Journal of Personalized Medicine mandibular advancement devices (MADs) obstructive sleep apnea (OSA) dental effects skeletal effects adults |
| title | Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis |
| title_full | Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis |
| title_fullStr | Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis |
| title_short | Dental and Skeletal Side Effects of Oral Appliances Used for the Treatment of Obstructive Sleep Apnea and Snoring in Adult Patients—A Systematic Review and Meta-Analysis |
| title_sort | dental and skeletal side effects of oral appliances used for the treatment of obstructive sleep apnea and snoring in adult patients a systematic review and meta analysis |
| topic | mandibular advancement devices (MADs) obstructive sleep apnea (OSA) dental effects skeletal effects adults |
| url | https://www.mdpi.com/2075-4426/12/3/483 |
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