Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children
Background: Helicobacter pylori infection is common in children. It results in a series of diseases such as peptic ulcer, iron deficiency anemia, reduced growth, and gastrointestinal malignancies. Every test to detect H. pylori has particular limitations. Moreover, various noninvasive methods have d...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2012-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2160 |
| _version_ | 1797728362572021760 |
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| author | Hosein Saneian Hamid Rahimi Nafiseh Sadat Mahmoodi |
| author_facet | Hosein Saneian Hamid Rahimi Nafiseh Sadat Mahmoodi |
| author_sort | Hosein Saneian |
| collection | DOAJ |
| description | Background: Helicobacter pylori infection is common in children. It results in a series of diseases such as peptic ulcer, iron deficiency anemia, reduced growth, and gastrointestinal malignancies. Every test to detect H. pylori has particular limitations. Moreover, various noninvasive methods have different sensitivity and specificity. We investigated the sensitivity of available diagnostic methods to identify the best noninvasive method for detection of H. pylori.
Methods: During a one-year period, 99 children who presented at Alzahra Hospital (Isfahan, Iran) with epigastric tenderness, abdominal pain at night, and early satiety were examined. They all underwent endoscopy and rapid urease and serologic tests. Stool samples were also obtained to detect H. pylori antigen. Culture was considered as the gold standard in diagnosis of H. pylori infection. The last step was the statistical analysis of the collected data.
Findings: According to culture results, 33% of the patients were positive for H. pylori infection. The sensitivity and specificity of urease test were 61.3% and 86.6%, respectively. The corresponding values were 74.1% and 98.3% for serological tests and 74.1% and 96.7% for H. pylori antigen detection in stool.
Conclusion: We found endoscopy to be the best method of H. pylori detection. Examining stool samples for the presence of H. pylori antigen and rapid urease test were the second and third methods in our ranking.
Keywords: Rapid urease test, Helicobacter pylori antigen in stool, Serologic test, Culture |
| first_indexed | 2024-03-12T11:12:53Z |
| format | Article |
| id | doaj.art-b400d418ae3c49afa4eb2314825adeaf |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T11:12:53Z |
| publishDate | 2012-12-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-b400d418ae3c49afa4eb2314825adeaf2023-09-02T02:30:59ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-12-0130212183918441193Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in ChildrenHosein Saneian0Hamid Rahimi1Nafiseh Sadat Mahmoodi2Assistant Professor, Department of Pediatric, School of Medicine AND Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Pediatric, School of Medicine AND Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Helicobacter pylori infection is common in children. It results in a series of diseases such as peptic ulcer, iron deficiency anemia, reduced growth, and gastrointestinal malignancies. Every test to detect H. pylori has particular limitations. Moreover, various noninvasive methods have different sensitivity and specificity. We investigated the sensitivity of available diagnostic methods to identify the best noninvasive method for detection of H. pylori. Methods: During a one-year period, 99 children who presented at Alzahra Hospital (Isfahan, Iran) with epigastric tenderness, abdominal pain at night, and early satiety were examined. They all underwent endoscopy and rapid urease and serologic tests. Stool samples were also obtained to detect H. pylori antigen. Culture was considered as the gold standard in diagnosis of H. pylori infection. The last step was the statistical analysis of the collected data. Findings: According to culture results, 33% of the patients were positive for H. pylori infection. The sensitivity and specificity of urease test were 61.3% and 86.6%, respectively. The corresponding values were 74.1% and 98.3% for serological tests and 74.1% and 96.7% for H. pylori antigen detection in stool. Conclusion: We found endoscopy to be the best method of H. pylori detection. Examining stool samples for the presence of H. pylori antigen and rapid urease test were the second and third methods in our ranking. Keywords: Rapid urease test, Helicobacter pylori antigen in stool, Serologic test, Culturehttp://jims.mui.ac.ir/index.php/jims/article/view/2160 |
| spellingShingle | Hosein Saneian Hamid Rahimi Nafiseh Sadat Mahmoodi Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children مجله دانشکده پزشکی اصفهان |
| title | Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children |
| title_full | Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children |
| title_fullStr | Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children |
| title_full_unstemmed | Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children |
| title_short | Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children |
| title_sort | comparison of the sensitivity and specificity of available methods in helicobacter pylori infection detection in children |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2160 |
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