Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat
The effects of orally consumed cadmium on the functions of the kidney have been investigated in rats based on the reported level of the toxicant in Warri River. Relative to the corresponding controls there were significant (P < 0.05) increases in the amount of cadmium in the kidneys of rats in al...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2005-09-01
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| Series: | Journal of Applied Sciences and Environmental Management |
| Online Access: | https://www.ajol.info/index.php/jasem/article/view/17222 |
| _version_ | 1797227851131387904 |
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| author | S O Asagba F O Obi |
| author_facet | S O Asagba F O Obi |
| author_sort | S O Asagba |
| collection | DOAJ |
| description | The effects of orally consumed cadmium on the functions of the kidney have been investigated in rats based on the reported level of the toxicant in Warri River. Relative to the corresponding controls there were significant (P < 0.05) increases in the amount of cadmium in the kidneys of rats in all the test groups. Biochemical analysis revealed significant (P < 0.05) changes in plasma creatinine after 2 months (control 1.20 ± 0.20 X 10-2; test 0.92 ± 0.26 X 10-2 µg/ml) and glucose after 1-month (control 91.67 ± 3.39; test 102.75 ± 5.99 mg/dL) exposure. Twenty-four hours urine volume were significantly decreased (P < 0.05) in rats exposed to cadmium for 1 and 2 months. Also in the Cd-exposed rats urine protein was significantly elevated in those exposed for 2 and 3 months but their urine glucose was demonstratively elevated only in those exposed for 2 months (control 33.00 ± 7.80; test 43.00 ±9.80 mg/dL). Urine creatinine was not significantly altered in any of the test groups. Consistently there were significant (P < 0.05) decreases in total ATPase and Mg2+ - ATPase activities at the end of the 2 and 3 months exposure when compared to the controls.
Journal of Applied Sciences and Environmental Management Vol. 8 (1) 2004: 29 - 32 |
| first_indexed | 2024-04-24T14:47:22Z |
| format | Article |
| id | doaj.art-b40212d7e554441a98f883259aacf4d2 |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T14:47:22Z |
| publishDate | 2005-09-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-b40212d7e554441a98f883259aacf4d22024-04-02T19:55:00ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992005-09-018110.4314/jasem.v8i1.17222Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the RatS O Asagba0F O Obi1Department of Biochemistry, Faculty of Science, Delta State University, Abraka, NigeriaDepartment of Biochemistry, Faculty of Science, University of Benin, Benin City, NigeriaThe effects of orally consumed cadmium on the functions of the kidney have been investigated in rats based on the reported level of the toxicant in Warri River. Relative to the corresponding controls there were significant (P < 0.05) increases in the amount of cadmium in the kidneys of rats in all the test groups. Biochemical analysis revealed significant (P < 0.05) changes in plasma creatinine after 2 months (control 1.20 ± 0.20 X 10-2; test 0.92 ± 0.26 X 10-2 µg/ml) and glucose after 1-month (control 91.67 ± 3.39; test 102.75 ± 5.99 mg/dL) exposure. Twenty-four hours urine volume were significantly decreased (P < 0.05) in rats exposed to cadmium for 1 and 2 months. Also in the Cd-exposed rats urine protein was significantly elevated in those exposed for 2 and 3 months but their urine glucose was demonstratively elevated only in those exposed for 2 months (control 33.00 ± 7.80; test 43.00 ±9.80 mg/dL). Urine creatinine was not significantly altered in any of the test groups. Consistently there were significant (P < 0.05) decreases in total ATPase and Mg2+ - ATPase activities at the end of the 2 and 3 months exposure when compared to the controls. Journal of Applied Sciences and Environmental Management Vol. 8 (1) 2004: 29 - 32https://www.ajol.info/index.php/jasem/article/view/17222 |
| spellingShingle | S O Asagba F O Obi Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat Journal of Applied Sciences and Environmental Management |
| title | Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat |
| title_full | Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat |
| title_fullStr | Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat |
| title_full_unstemmed | Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat |
| title_short | Effects of Oral Cadmium Exposure on Renal Glomerular and Tubular Functions in the Rat |
| title_sort | effects of oral cadmium exposure on renal glomerular and tubular functions in the rat |
| url | https://www.ajol.info/index.php/jasem/article/view/17222 |
| work_keys_str_mv | AT soasagba effectsoforalcadmiumexposureonrenalglomerularandtubularfunctionsintherat AT foobi effectsoforalcadmiumexposureonrenalglomerularandtubularfunctionsintherat |