Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000
ObjectiveCurrent evidence on the associations between plasma thyroid stimulating hormone and Helicobacter pylori infection is conflicting. Therefore, our study aimed to examine TSH in relation to H. pylori infection.MethodsBased on the US National Health and Nutrition Examination Survey (NHANES) 199...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1018267/full |
| _version_ | 1797984291518414848 |
|---|---|
| author | Jinyun Wang Jinyun Wang Jinyun Wang Dingwei Liu Dingwei Liu Dingwei Liu Yong Xie Yong Xie Yong Xie |
| author_facet | Jinyun Wang Jinyun Wang Jinyun Wang Dingwei Liu Dingwei Liu Dingwei Liu Yong Xie Yong Xie Yong Xie |
| author_sort | Jinyun Wang |
| collection | DOAJ |
| description | ObjectiveCurrent evidence on the associations between plasma thyroid stimulating hormone and Helicobacter pylori infection is conflicting. Therefore, our study aimed to examine TSH in relation to H. pylori infection.MethodsBased on the US National Health and Nutrition Examination Survey (NHANES) 1999-2000, a cross-sectional study was conducted with 948 participants aged 30 to 85 years. The associations between H. pylori seropositivity and TSH were evaluated using binary logistic regression models. A subgroup analysis stratified by sex, age, and body mass index was conducted.ResultsA higher serum TSH level was found in subjects with H. pylori seropositive than in subjects with H. pylori seronegative. A significant positive association was found between H. pylori seropositivity and TSH with increasing quartiles of hormonal levels in univariate regression models (Q4 vs Q1: OR = 1.659; 95% CI, 1.152-2.389) and in multivariate regression models (Q4 vs Q1: OR = 1.604; 95% CI, 1.087-2.367). In stratified analyses, the adjusted association of serum TSH with H. pylori seropositivity was statistically significant in male (Q4 vs Q1: OR = 1.894; 95% CI, 1.109-3.235), normal BMI (Q4 vs Q1: OR = 1.894; 95% CI, 1.109-3.235), overweight (Q4 vs Q1: OR = 2.124; 95% CI, 1.047-4.308);, obese (Q4 vs Q1: OR = 0.429; 95% CI, 0.220-0.837), and age over 60 years (Q4 vs Q1: OR = 1.999; 95% CI, 1.118-3.575).ConclusionHigh TSH levels were associated with H. pylori infection, especially among male, overweight and elderly adults. |
| first_indexed | 2024-04-11T06:59:16Z |
| format | Article |
| id | doaj.art-b40468f8b33c41dcb33c70f9530dad28 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T06:59:16Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b40468f8b33c41dcb33c70f9530dad282022-12-22T04:38:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10182671018267Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000Jinyun Wang0Jinyun Wang1Jinyun Wang2Dingwei Liu3Dingwei Liu4Dingwei Liu5Yong Xie6Yong Xie7Yong Xie8Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, JiangXi Clinical Research Center for Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, JiangXi Clinical Research Center for Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastroenterology, JiangXi Clinical Research Center for Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaObjectiveCurrent evidence on the associations between plasma thyroid stimulating hormone and Helicobacter pylori infection is conflicting. Therefore, our study aimed to examine TSH in relation to H. pylori infection.MethodsBased on the US National Health and Nutrition Examination Survey (NHANES) 1999-2000, a cross-sectional study was conducted with 948 participants aged 30 to 85 years. The associations between H. pylori seropositivity and TSH were evaluated using binary logistic regression models. A subgroup analysis stratified by sex, age, and body mass index was conducted.ResultsA higher serum TSH level was found in subjects with H. pylori seropositive than in subjects with H. pylori seronegative. A significant positive association was found between H. pylori seropositivity and TSH with increasing quartiles of hormonal levels in univariate regression models (Q4 vs Q1: OR = 1.659; 95% CI, 1.152-2.389) and in multivariate regression models (Q4 vs Q1: OR = 1.604; 95% CI, 1.087-2.367). In stratified analyses, the adjusted association of serum TSH with H. pylori seropositivity was statistically significant in male (Q4 vs Q1: OR = 1.894; 95% CI, 1.109-3.235), normal BMI (Q4 vs Q1: OR = 1.894; 95% CI, 1.109-3.235), overweight (Q4 vs Q1: OR = 2.124; 95% CI, 1.047-4.308);, obese (Q4 vs Q1: OR = 0.429; 95% CI, 0.220-0.837), and age over 60 years (Q4 vs Q1: OR = 1.999; 95% CI, 1.118-3.575).ConclusionHigh TSH levels were associated with H. pylori infection, especially among male, overweight and elderly adults.https://www.frontiersin.org/articles/10.3389/fendo.2022.1018267/fullthyroid stimulating hormoneTSHHelicobacter pylori infectionNHANESCDC |
| spellingShingle | Jinyun Wang Jinyun Wang Jinyun Wang Dingwei Liu Dingwei Liu Dingwei Liu Yong Xie Yong Xie Yong Xie Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 Frontiers in Endocrinology thyroid stimulating hormone TSH Helicobacter pylori infection NHANES CDC |
| title | Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 |
| title_full | Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 |
| title_fullStr | Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 |
| title_full_unstemmed | Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 |
| title_short | Association between Helicobacter pylori infection and serum thyroid stimulating hormone in the National Health and Nutrition Examination Survey 1999-2000 |
| title_sort | association between helicobacter pylori infection and serum thyroid stimulating hormone in the national health and nutrition examination survey 1999 2000 |
| topic | thyroid stimulating hormone TSH Helicobacter pylori infection NHANES CDC |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1018267/full |
| work_keys_str_mv | AT jinyunwang associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT jinyunwang associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT jinyunwang associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT dingweiliu associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT dingweiliu associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT dingweiliu associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT yongxie associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT yongxie associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 AT yongxie associationbetweenhelicobacterpyloriinfectionandserumthyroidstimulatinghormoneinthenationalhealthandnutritionexaminationsurvey19992000 |