Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy

Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy

Currently, no curative treatment is available for spinal muscular atrophy (SMA). Since the degeneration of spinal motor neurons in SMA is mediated by apoptosis, over-expression of an anti-apoptotic factor, Bcl-xL, may benefit SMA. Here, we crossed a mouse model of SMA with Bcl-xL transgenic mice to...

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Bibliographic Details
Main Authors: Li-Kai Tsai, Ming-Shiun Tsai, Chen-Hung Ting, Sue-Hong Wang, Hung Li
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neurobiology of Disease
Subjects:
Apoptosis
Bcl-xL
Motor neuron disease
Spinal muscular atrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001046

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