The History of Flow Chemistry at Eli Lilly and Company
Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydro...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2023-05-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/6264 |
| _version_ | 1797814499884924928 |
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| author | Martin D. Johnson Timothy Braden Joel R. Calvin Alison Campbell Brewer Kevin P. Cole Scott Frank Mark Kerr Doug Kjell Michael E. Kopach Joseph R. Martinelli Scott. A. May Juan Rincon Timothy D. White Matthew H. Yates |
| author_facet | Martin D. Johnson Timothy Braden Joel R. Calvin Alison Campbell Brewer Kevin P. Cole Scott Frank Mark Kerr Doug Kjell Michael E. Kopach Joseph R. Martinelli Scott. A. May Juan Rincon Timothy D. White Matthew H. Yates |
| author_sort | Martin D. Johnson |
| collection | DOAJ |
| description |
Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydroformylation, and thermal imidazole cyclization. Next, flow chemistry was used to enable safe scale up of hazardous chemistries to manufacturing plants. Examples included high pressure hydrogenation, aerobic oxidation, and Grignard formation reactions. More recently, flow chemistry was used in Small Volume Continuous (SVC) processes, where highly potent oncolytic molecules were produced by fully continuous processes at about 10 kg/day including reaction, extraction, distillation, and crystallization, using disposable equipment contained in fume hoods.
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| first_indexed | 2024-03-13T08:08:39Z |
| format | Article |
| id | doaj.art-b4057d6508d9480596cdbdfe9135202f |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-03-13T08:08:39Z |
| publishDate | 2023-05-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-b4057d6508d9480596cdbdfe9135202f2023-06-01T00:15:10ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242023-05-0177510.2533/chimia.2023.319The History of Flow Chemistry at Eli Lilly and CompanyMartin D. Johnson0Timothy Braden1Joel R. Calvin2Alison Campbell Brewer3Kevin P. Cole4Scott Frank5Mark Kerr6Doug Kjell7Michael E. Kopach8Joseph R. Martinelli9Scott. A. May10Juan Rincon11Timothy D. White12Matthew H. Yates13Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285 Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydroformylation, and thermal imidazole cyclization. Next, flow chemistry was used to enable safe scale up of hazardous chemistries to manufacturing plants. Examples included high pressure hydrogenation, aerobic oxidation, and Grignard formation reactions. More recently, flow chemistry was used in Small Volume Continuous (SVC) processes, where highly potent oncolytic molecules were produced by fully continuous processes at about 10 kg/day including reaction, extraction, distillation, and crystallization, using disposable equipment contained in fume hoods. https://www.chimia.ch/chimia/article/view/6264Flow chemistryIndustrial productionSmall Volume Continuous (SVC) process |
| spellingShingle | Martin D. Johnson Timothy Braden Joel R. Calvin Alison Campbell Brewer Kevin P. Cole Scott Frank Mark Kerr Doug Kjell Michael E. Kopach Joseph R. Martinelli Scott. A. May Juan Rincon Timothy D. White Matthew H. Yates The History of Flow Chemistry at Eli Lilly and Company CHIMIA Flow chemistry Industrial production Small Volume Continuous (SVC) process |
| title | The History of Flow Chemistry at Eli Lilly and Company |
| title_full | The History of Flow Chemistry at Eli Lilly and Company |
| title_fullStr | The History of Flow Chemistry at Eli Lilly and Company |
| title_full_unstemmed | The History of Flow Chemistry at Eli Lilly and Company |
| title_short | The History of Flow Chemistry at Eli Lilly and Company |
| title_sort | history of flow chemistry at eli lilly and company |
| topic | Flow chemistry Industrial production Small Volume Continuous (SVC) process |
| url | https://www.chimia.ch/chimia/article/view/6264 |
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