| Summary: | INTRODUCTION[|]The aim of the present study was to discuss the effects of antagonism of neuromuscular blockade with sugammadex on extubation success and residual curarization in neonates with retrospective data.[¤]METHODS[|]The present study was conducted as a retrospective analysis of the data of 27 neonates aged ≤40 days who underwent abdominal surgery between January 2012 and December 2013. Rocuronium was used for anesthesia induction, and patients whose neuromuscular blockade was antagonized by sugammadex and who were monitored with train-of-four (TOF) were included in the study. The dose of rocuronium administered, the dose of sugammadex, the duration of the operation and anesthesia, elapsed time from the last dose of rocuronium to sugammadex administration and elapsed time from sugammadex administration to extubation, and TOF values during extubation were recorded from the anesthesia records.
[¤]RESULTS[|]The mean age of the patients was 10.29+-11.80 days. The mean weight was 3.04+-1.92 kg. The mean sugammadex dose was 3.6 mg/kg. The elapsed time from the last rocuronium to sugammadex administration was 27.3+-7.7 min, the elapsed time from sugammadex administration to extubation was 1.05+-0.6 min, and the TOF value during extubation was 93.5+-7.3. The time to reach TOF 0.9 was 88.11+-21.06 s.
[¤]DISCUSSION AND CONCLUSION[|]Sugammadex, which is used for the reversal of neuromuscular blockade in neonates, showed a similar efficacy as in adult and pediatric patient studies. Safe extubation can be performed in neonates in a short period with sugammadex.[¤]
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