Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT
Abstract Background: Functional assessment to rule out myocardial ischemia using coronary computed tomography angiography (CCTA) is extremely important and data on the Brazilian population are still limited. Objective: To assess the diagnostic performance of myocardial perfusion by CCTA in the det...
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Sociedade Brasileira de Cardiologia (SBC)
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005019103&lng=en&tlng=en |
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| author | Wilter dos Santos Ker Daniel Gama das Neves Tiago Augusto Magalhães Alair Augusto Sarmet M. D. dos Santos Claudio Tinoco Mesquita Marcelo Souto Nacif |
| author_facet | Wilter dos Santos Ker Daniel Gama das Neves Tiago Augusto Magalhães Alair Augusto Sarmet M. D. dos Santos Claudio Tinoco Mesquita Marcelo Souto Nacif |
| author_sort | Wilter dos Santos Ker |
| collection | DOAJ |
| description | Abstract Background: Functional assessment to rule out myocardial ischemia using coronary computed tomography angiography (CCTA) is extremely important and data on the Brazilian population are still limited. Objective: To assess the diagnostic performance of myocardial perfusion by CCTA in the detection of severe obstructive coronary artery disease (CAD) compared with single-photon emission computerized tomography (SPECT). To analyze the importance of anatomical knowledge to understand the presence of myocardial perfusion defects on SPECT imaging that is not identified on computed tomography (CT) scan. Method: A total of 35 patients were evaluated by a simultaneous pharmacologic stress protocol. Fisher’s exact test was used to compare proportions. The patients were grouped according to the presence or absence of significant CAD. The area under the ROC curve was used to identify the diagnostic performance of CCTA and SPECT in perfusion assessment. P < 0.05 values were considered statistically significant. Results: For detection of obstructive CAD, CT myocardial perfusion analysis yielded an area under the ROC curve of 0.84 [a 95% confidence interval (CI95%): 0.67-0.94, p < 0.001]. SPECT myocardial perfusion imaging, on the other hand, showed an AUC of 0.58 (95% CI 0.40 - 0.74, p < 0.001). In this study, false-positive results with SPECT are described. Conclusion: Myocardial perfusion analysis by CTA displays satisfactory results compared to SPECT in the detection of obstructive CAD. CCTA can rule out false-positive results of SPECT. |
| first_indexed | 2024-12-11T12:41:51Z |
| format | Article |
| id | doaj.art-b4071a84ed7f4602a3b9b3b74c178048 |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-12-11T12:41:51Z |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-b4071a84ed7f4602a3b9b3b74c1780482022-12-22T01:06:56ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-417010.5935/abc.20190201S0066-782X2019005019103Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECTWilter dos Santos KerDaniel Gama das NevesTiago Augusto MagalhãesAlair Augusto Sarmet M. D. dos SantosClaudio Tinoco MesquitaMarcelo Souto NacifAbstract Background: Functional assessment to rule out myocardial ischemia using coronary computed tomography angiography (CCTA) is extremely important and data on the Brazilian population are still limited. Objective: To assess the diagnostic performance of myocardial perfusion by CCTA in the detection of severe obstructive coronary artery disease (CAD) compared with single-photon emission computerized tomography (SPECT). To analyze the importance of anatomical knowledge to understand the presence of myocardial perfusion defects on SPECT imaging that is not identified on computed tomography (CT) scan. Method: A total of 35 patients were evaluated by a simultaneous pharmacologic stress protocol. Fisher’s exact test was used to compare proportions. The patients were grouped according to the presence or absence of significant CAD. The area under the ROC curve was used to identify the diagnostic performance of CCTA and SPECT in perfusion assessment. P < 0.05 values were considered statistically significant. Results: For detection of obstructive CAD, CT myocardial perfusion analysis yielded an area under the ROC curve of 0.84 [a 95% confidence interval (CI95%): 0.67-0.94, p < 0.001]. SPECT myocardial perfusion imaging, on the other hand, showed an AUC of 0.58 (95% CI 0.40 - 0.74, p < 0.001). In this study, false-positive results with SPECT are described. Conclusion: Myocardial perfusion analysis by CTA displays satisfactory results compared to SPECT in the detection of obstructive CAD. CCTA can rule out false-positive results of SPECT.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005019103&lng=en&tlng=enDoença da Artéria Coronariana/fisiopatologiaIsquemia MiocárdicaTomografia Computadorizada de Emissão de Fóton Único/métodosImagem de Perfusão do MiocárdioCineangiografia/métodos |
| spellingShingle | Wilter dos Santos Ker Daniel Gama das Neves Tiago Augusto Magalhães Alair Augusto Sarmet M. D. dos Santos Claudio Tinoco Mesquita Marcelo Souto Nacif Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT Arquivos Brasileiros de Cardiologia Doença da Artéria Coronariana/fisiopatologia Isquemia Miocárdica Tomografia Computadorizada de Emissão de Fóton Único/métodos Imagem de Perfusão do Miocárdio Cineangiografia/métodos |
| title | Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT |
| title_full | Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT |
| title_fullStr | Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT |
| title_full_unstemmed | Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT |
| title_short | Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT |
| title_sort | myocardial perfusion by coronary computed tomography in the evaluation of myocardial ischemia simultaneous stress protocol with spect |
| topic | Doença da Artéria Coronariana/fisiopatologia Isquemia Miocárdica Tomografia Computadorizada de Emissão de Fóton Único/métodos Imagem de Perfusão do Miocárdio Cineangiografia/métodos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005019103&lng=en&tlng=en |
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