Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro

Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro

IntroductionTumor-associated macrophages (TAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype and function of these cells. The present study aims to characterize macrophages in high-grade serous ovarian cancer (HGSOC).MethodsPhenoty...

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Bibliographic Details
Main Authors: Franziska Brauneck, Leticia Oliveira-Ferrer, Jana Muschhammer, Tabea Sturmheit, Christin Ackermann, Friedrich Haag, Julian Schulze zur Wiesch, Yi Ding, Minyue Qi, Louisa Hell, Barbara Schmalfeldt, Carsten Bokemeyer, Walter Fiedler, Jasmin Wellbrock
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
High-grade serous ovarian cancer (HGSOC)
tumor-associated macrophages (TAMs)
TIGIT
repolarization
CD47
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250258/full

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