Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model

Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model

Co-culture models have become mandatory for obtaining better insights into bone homeostasis, which relies on the balance between osteoblasts and osteoclasts. Cigarette smoking (CS) has been proven to increase the risk of osteoporosis; however, there is currently no proven treatment for osteoporosis...

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Bibliographic Details
Main Authors: Sheng Zhu, Victor Häussling, Romina H. Aspera-Werz, Tao Chen, Bianca Braun, Weidong Weng, Tina Histing, Andreas K. Nussler
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
co-culture
osteoblasts
osteoclasts
cigarette smoking
bisphosphonates
osteoporosis
Online Access:https://www.mdpi.com/1422-0067/22/1/53

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