Imatinib-induced interstitial pneumonitis – a literature review and case report
Imatinib is generally well tolerated, with mild common side effects such as nausea and vomiting, diarrhea, muscle cramps, fatigue, skin rash and edema; however, pulmonary complications are uncommon. A 73-year-old woman undergoing one month treatment with Imatinib for chronic myeloid neoplasm associa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ion Motofei, Carol Davila University
2020-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1227&context=jmms |
| _version_ | 1819140069112414208 |
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| author | Olga Hilda Orasan Andreea Maria Stefan Iulia Minciuna Adela Sitar-Taut George Ciulei Simina Tarmure Ioana Para Flaviu Muresan Ovidiu Fabian Sorina Cezara Coste Vasile Negrean Angela Cozma Laura Urian |
| author_facet | Olga Hilda Orasan Andreea Maria Stefan Iulia Minciuna Adela Sitar-Taut George Ciulei Simina Tarmure Ioana Para Flaviu Muresan Ovidiu Fabian Sorina Cezara Coste Vasile Negrean Angela Cozma Laura Urian |
| author_sort | Olga Hilda Orasan |
| collection | DOAJ |
| description | Imatinib is generally well tolerated, with mild common side effects such as nausea and vomiting, diarrhea, muscle cramps, fatigue, skin rash and edema; however, pulmonary complications are uncommon. A 73-year-old woman undergoing one month treatment with Imatinib for chronic myeloid neoplasm associated with eosinophilia was admitted for sudden alteration of her performance status, dyspnea at rest and productive cough. On clinical examination, the patient was hypoxic (oxygen saturation on room air was 87%), and auscultation of her lungs revealed diffuse bilateral fine crackles. Computed tomography showed bilateral pulmonary interstitial syndrome. Imatinib was discontinued and the patient received systemic corticosteroid therapy and oxygen therapy. After one month, the symptoms and radiological findings were resolved. When Imatinib therapy was resumed, respiratory symptoms reappeared, which is why treatment with Imatinib was interrupted. Imatinib-induced pneumonitis should take into consideration when patients develop respiratory symptoms or abnormal pulmonary radiological features. |
| first_indexed | 2024-12-22T11:32:41Z |
| format | Article |
| id | doaj.art-b40bb6103ec346988c4b636c7da55211 |
| institution | Directory Open Access Journal |
| issn | 2392-7674 2392-7674 |
| language | English |
| last_indexed | 2024-12-22T11:32:41Z |
| publishDate | 2020-04-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-b40bb6103ec346988c4b636c7da552112022-12-21T18:27:34ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742392-76742020-04-0171949910.22543/7674.71.P9499Imatinib-induced interstitial pneumonitis – a literature review and case reportOlga Hilda Orasan0Andreea Maria Stefan1Iulia Minciuna2Adela Sitar-Taut3George Ciulei4Simina Tarmure5Ioana Para6Flaviu Muresan7Ovidiu Fabian8Sorina Cezara Coste9Vasile Negrean10Angela Cozma11Laura Urian12IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; PROF. DR. OCTAVIAN FODOR REGIONAL INSTITUTE OF GASTROENTEROLOGY AND HEPATOLOGY, CLUJ-NAPOCA, ROMANIA; PROF. DR. OCTAVIAN FODOR REGIONAL INSTITUTE OF GASTROENTEROLOGY AND HEPATOLOGY, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; PROF. DR. OCTAVIAN FODOR REGIONAL INSTITUTE OF GASTROENTEROLOGY AND HEPATOLOGY, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH SURGICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH SURGICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; PROF. DR. OCTAVIAN FODOR REGIONAL INSTITUTE OF GASTROENTEROLOGY AND HEPATOLOGY, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, 4TH MEDICAL DEPARTMENT, CLUJ-NAPOCA, ROMANIA; IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY CLUJ-NAPOCA, HEMATOLOGY DEPARTMENT, CLUJ-NAPOCA, ROMANIA;Imatinib is generally well tolerated, with mild common side effects such as nausea and vomiting, diarrhea, muscle cramps, fatigue, skin rash and edema; however, pulmonary complications are uncommon. A 73-year-old woman undergoing one month treatment with Imatinib for chronic myeloid neoplasm associated with eosinophilia was admitted for sudden alteration of her performance status, dyspnea at rest and productive cough. On clinical examination, the patient was hypoxic (oxygen saturation on room air was 87%), and auscultation of her lungs revealed diffuse bilateral fine crackles. Computed tomography showed bilateral pulmonary interstitial syndrome. Imatinib was discontinued and the patient received systemic corticosteroid therapy and oxygen therapy. After one month, the symptoms and radiological findings were resolved. When Imatinib therapy was resumed, respiratory symptoms reappeared, which is why treatment with Imatinib was interrupted. Imatinib-induced pneumonitis should take into consideration when patients develop respiratory symptoms or abnormal pulmonary radiological features.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1227&context=jmmsimatinib-induced pneumonitisantineoplastic agentsadverse drug reactions |
| spellingShingle | Olga Hilda Orasan Andreea Maria Stefan Iulia Minciuna Adela Sitar-Taut George Ciulei Simina Tarmure Ioana Para Flaviu Muresan Ovidiu Fabian Sorina Cezara Coste Vasile Negrean Angela Cozma Laura Urian Imatinib-induced interstitial pneumonitis – a literature review and case report Journal of Mind and Medical Sciences imatinib-induced pneumonitis antineoplastic agents adverse drug reactions |
| title | Imatinib-induced interstitial pneumonitis – a literature review and case report |
| title_full | Imatinib-induced interstitial pneumonitis – a literature review and case report |
| title_fullStr | Imatinib-induced interstitial pneumonitis – a literature review and case report |
| title_full_unstemmed | Imatinib-induced interstitial pneumonitis – a literature review and case report |
| title_short | Imatinib-induced interstitial pneumonitis – a literature review and case report |
| title_sort | imatinib induced interstitial pneumonitis a literature review and case report |
| topic | imatinib-induced pneumonitis antineoplastic agents adverse drug reactions |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1227&context=jmms |
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