Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age
Aim: This study aims to describe prevalence and clinical significance of latent Brugada syndrome (BrS) in a young population with atrial fibrillation (AF).Methods: Between September 2015 and November 2017, among 111 AF patients below 45 years of age, those without pre-existing pathologies and/or kno...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2020.602536/full |
| _version_ | 1818245295479193600 |
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| author | Ramadan Ghaleb Matteo Anselmino Luca Gaido Stefano Quaranta Carla Giustetto Mohammed Kamal Salama Ayman Salh Marco Scaglione Enas Fathy Fiorenzo Gaita |
| author_facet | Ramadan Ghaleb Matteo Anselmino Luca Gaido Stefano Quaranta Carla Giustetto Mohammed Kamal Salama Ayman Salh Marco Scaglione Enas Fathy Fiorenzo Gaita |
| author_sort | Ramadan Ghaleb |
| collection | DOAJ |
| description | Aim: This study aims to describe prevalence and clinical significance of latent Brugada syndrome (BrS) in a young population with atrial fibrillation (AF).Methods: Between September 2015 and November 2017, among 111 AF patients below 45 years of age, those without pre-existing pathologies and/or known risk factors were selected for the study. Based on baseline 12-lead−24-h Holter electrocardiogram (ECG), previous class 1C antiarrhythmic drug therapy, or ajmaline testing, patients were stratified as latent type 1 BrS or not.Results: Within the 78 enrolled patients, 13 (16.7%; group 1) revealed a type 1 BrS ECG pattern, while 65 (83.3%; group 2) did not. Mean age was 37 ± 8 vs. 35 ± 7 (p = 0.42), and males were 7 (54%) vs. 54 (83%) (p = 0.02) in the two groups, respectively. Family history of BrS was significantly more common within group 1 patients (2, 15% vs. 0; p = 0.03), and 4 (31%) patients experienced syncope in group 1 vs. 5 (8%) in group 2 (p = 0.02). After a mean follow-up of 42 ± 18 months from the index AF event, more than 80% of the patients, in both study groups, were in sinus rhythm.Conclusion: In young patients with AF without pre-existing pathologies and/or known risk factors, latent BrS should be suspected. Syncope and a family history of BrS emerge as easily identifiable factors related to BrS. Long-term sinus rhythm maintenance appears satisfactory, either in the presence or not of BrS. |
| first_indexed | 2024-12-12T14:30:39Z |
| format | Article |
| id | doaj.art-b40c3ed402574c9ba1ce9c2695428c34 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T14:30:39Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b40c3ed402574c9ba1ce9c2695428c342022-12-22T00:21:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-11-01710.3389/fcvm.2020.602536602536Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of AgeRamadan Ghaleb0Matteo Anselmino1Luca Gaido2Stefano Quaranta3Carla Giustetto4Mohammed Kamal Salama5Ayman Salh6Marco Scaglione7Enas Fathy8Fiorenzo Gaita9Department of Cardiovascular Medicine, Aswan University Hospital, Aswan, EgyptDivision of Cardiology, Department of Medical Sciences, “Città della Salute e della Scienza di Torino” Hospital, University of Turin, Turin, ItalyDivision of Cardiology, Department of Medical Sciences, “Città della Salute e della Scienza di Torino” Hospital, University of Turin, Turin, ItalyDivision of Cardiology, Department of Medical Sciences, “Città della Salute e della Scienza di Torino” Hospital, University of Turin, Turin, ItalyDivision of Cardiology, Department of Medical Sciences, “Città della Salute e della Scienza di Torino” Hospital, University of Turin, Turin, ItalyDepartment of Cardiovascular Medicine, Kafr El-Sheikh University Hospital, Kafr El-Sheikh, EgyptDepartment of Cardiovascular Medicine, Ain Shams University Hospital, Cairo, EgyptDivision of Cardiology, “Cardinal Massaia” Hospital, Asti, ItalyDepartment of Cardiovascular Medicine, Aswan University Hospital, Aswan, EgyptDivision of Cardiology, Department of Medical Sciences, “Città della Salute e della Scienza di Torino” Hospital, University of Turin, Turin, ItalyAim: This study aims to describe prevalence and clinical significance of latent Brugada syndrome (BrS) in a young population with atrial fibrillation (AF).Methods: Between September 2015 and November 2017, among 111 AF patients below 45 years of age, those without pre-existing pathologies and/or known risk factors were selected for the study. Based on baseline 12-lead−24-h Holter electrocardiogram (ECG), previous class 1C antiarrhythmic drug therapy, or ajmaline testing, patients were stratified as latent type 1 BrS or not.Results: Within the 78 enrolled patients, 13 (16.7%; group 1) revealed a type 1 BrS ECG pattern, while 65 (83.3%; group 2) did not. Mean age was 37 ± 8 vs. 35 ± 7 (p = 0.42), and males were 7 (54%) vs. 54 (83%) (p = 0.02) in the two groups, respectively. Family history of BrS was significantly more common within group 1 patients (2, 15% vs. 0; p = 0.03), and 4 (31%) patients experienced syncope in group 1 vs. 5 (8%) in group 2 (p = 0.02). After a mean follow-up of 42 ± 18 months from the index AF event, more than 80% of the patients, in both study groups, were in sinus rhythm.Conclusion: In young patients with AF without pre-existing pathologies and/or known risk factors, latent BrS should be suspected. Syncope and a family history of BrS emerge as easily identifiable factors related to BrS. Long-term sinus rhythm maintenance appears satisfactory, either in the presence or not of BrS.https://www.frontiersin.org/articles/10.3389/fcvm.2020.602536/fullsudden cardiac deathclass 1 antiarrhythmic drugsBrugada syndromeatrial fibrillationtranscatheter ablation |
| spellingShingle | Ramadan Ghaleb Matteo Anselmino Luca Gaido Stefano Quaranta Carla Giustetto Mohammed Kamal Salama Ayman Salh Marco Scaglione Enas Fathy Fiorenzo Gaita Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age Frontiers in Cardiovascular Medicine sudden cardiac death class 1 antiarrhythmic drugs Brugada syndrome atrial fibrillation transcatheter ablation |
| title | Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age |
| title_full | Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age |
| title_fullStr | Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age |
| title_full_unstemmed | Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age |
| title_short | Prevalence and Clinical Significance of Latent Brugada Syndrome in Atrial Fibrillation Patients Below 45 Years of Age |
| title_sort | prevalence and clinical significance of latent brugada syndrome in atrial fibrillation patients below 45 years of age |
| topic | sudden cardiac death class 1 antiarrhythmic drugs Brugada syndrome atrial fibrillation transcatheter ablation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2020.602536/full |
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