Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation
Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00108/full |
| _version_ | 1818043001107120128 |
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| author | Xuewei Chen Liwei Zhang Danfeng Yang Chao Li Gaihong An Jing Wang Yongcong Shao Rong Fan Qiang Ma |
| author_facet | Xuewei Chen Liwei Zhang Danfeng Yang Chao Li Gaihong An Jing Wang Yongcong Shao Rong Fan Qiang Ma |
| author_sort | Xuewei Chen |
| collection | DOAJ |
| description | Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD.Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design.Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD.Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual’s arousal level and accelerated response-related decisions, while subjects’ higher-level recognition had limited improvement with prolonged awareness. |
| first_indexed | 2024-12-10T08:55:16Z |
| format | Article |
| id | doaj.art-b40cf928e80a4aeeb48fb1e0dddde4d7 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T08:55:16Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-b40cf928e80a4aeeb48fb1e0dddde4d72022-12-22T01:55:26ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532020-06-011410.3389/fnbeh.2020.00108521008Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep DeprivationXuewei Chen0Liwei Zhang1Danfeng Yang2Chao Li3Gaihong An4Jing Wang5Yongcong Shao6Rong Fan7Qiang Ma8Department of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences (CAS), Beijing, ChinaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaSchool of Psychology, Beijing Sport University, Beijing, ChinaCentral Laboratory, Xi Qing Hospital, Tianjin, ChinaDepartment of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, ChinaObjective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD.Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design.Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD.Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual’s arousal level and accelerated response-related decisions, while subjects’ higher-level recognition had limited improvement with prolonged awareness.https://www.frontiersin.org/article/10.3389/fnbeh.2020.00108/fullcaffeineERPtotal sleep deprivationGo/ No-Goreaction time (RTs) |
| spellingShingle | Xuewei Chen Liwei Zhang Danfeng Yang Chao Li Gaihong An Jing Wang Yongcong Shao Rong Fan Qiang Ma Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation Frontiers in Behavioral Neuroscience caffeine ERP total sleep deprivation Go/ No-Go reaction time (RTs) |
| title | Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation |
| title_full | Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation |
| title_fullStr | Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation |
| title_full_unstemmed | Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation |
| title_short | Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation |
| title_sort | effects of caffeine on event related potentials and neuropsychological indices after sleep deprivation |
| topic | caffeine ERP total sleep deprivation Go/ No-Go reaction time (RTs) |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00108/full |
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