Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria
Objectives: Because of lack of data on the prevalence of sulfadoxine antibody, this study was conducted to determine the prevalence of sulfadoxine antibodies and its possible risk factors. Methods: Blood specimens were collected from 500 patients undergoing treatment for malaria at Central Hospital,...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2017-05-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://omjournal.org/articleDetails.aspx?coType=1&aId=1964 |
| _version_ | 1818232253299294208 |
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| author | Kingsley Ikuoyogie Helen Oroboghae Ogefere Richard Omoregie |
| author_facet | Kingsley Ikuoyogie Helen Oroboghae Ogefere Richard Omoregie |
| author_sort | Kingsley Ikuoyogie |
| collection | DOAJ |
| description | Objectives: Because of lack of data on the prevalence of sulfadoxine antibody, this study was conducted to determine the prevalence of sulfadoxine antibodies and its possible risk factors. Methods: Blood specimens were collected from 500 patients undergoing treatment for malaria at Central Hospital, Benin City, Nigeria. A structured questionnaire was used to collect information and sociodemographic data. Sulfadoxine antibodies were detected by drug absorption (DAT) and immune complex (IMC) methods. ABO, rhesus blood group, and hemoglobin (Hb) phenotype were determined by using standard technique. Results: DAT method had a significantly higher rate of detecting sulfadoxine antibodies compared to IMC method (p = 0.019). Age, gender, and level of education did not affect the prevalence of sulfadoxine antibodies (p > 0.050). Patients that were an artisan (p < 0.001), married (p = 0.025), living in a two-room apartment (p = 0.003), had history of drug reaction, consumed antimalarial drug (maloxine), and consumed sulfadoxine-containing drug within the last month (p < 0.001 each), and significantly affected the prevalence of sulfadoxine antibodies. Individuals with Hb phenotype AA had significantly higher prevalence of sulfadoxine antibodies (p < 0.001), and presence of rhesus D antigen was associated with sulfadoxine antibodies. Conclusions: An overall prevalence of 22.0% among the tested individuals had sulfadoxine antibodies. Prudent use of sulfadoxine containing drugs is advocated. |
| first_indexed | 2024-12-12T11:03:21Z |
| format | Article |
| id | doaj.art-b40f1af9fe18498c86d8c056ab6603fa |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-12T11:03:21Z |
| publishDate | 2017-05-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-b40f1af9fe18498c86d8c056ab6603fa2022-12-22T00:26:28ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042017-05-0132320721310.5001/omj.2017.39Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, NigeriaKingsley Ikuoyogie0Helen Oroboghae Ogefere1Richard Omoregie2Divine Favour Medical Laboratories, Benin City, Nigeria; Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, NigerDepartment of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, NigerMedical Microbiology Unit, Medical Laboratory Services, University of Benin Teaching Hospital, Benin City, Nigeria; School of Medical Laboratory Science, University of Benin Teaching Hospital, Benin City, NigeriaObjectives: Because of lack of data on the prevalence of sulfadoxine antibody, this study was conducted to determine the prevalence of sulfadoxine antibodies and its possible risk factors. Methods: Blood specimens were collected from 500 patients undergoing treatment for malaria at Central Hospital, Benin City, Nigeria. A structured questionnaire was used to collect information and sociodemographic data. Sulfadoxine antibodies were detected by drug absorption (DAT) and immune complex (IMC) methods. ABO, rhesus blood group, and hemoglobin (Hb) phenotype were determined by using standard technique. Results: DAT method had a significantly higher rate of detecting sulfadoxine antibodies compared to IMC method (p = 0.019). Age, gender, and level of education did not affect the prevalence of sulfadoxine antibodies (p > 0.050). Patients that were an artisan (p < 0.001), married (p = 0.025), living in a two-room apartment (p = 0.003), had history of drug reaction, consumed antimalarial drug (maloxine), and consumed sulfadoxine-containing drug within the last month (p < 0.001 each), and significantly affected the prevalence of sulfadoxine antibodies. Individuals with Hb phenotype AA had significantly higher prevalence of sulfadoxine antibodies (p < 0.001), and presence of rhesus D antigen was associated with sulfadoxine antibodies. Conclusions: An overall prevalence of 22.0% among the tested individuals had sulfadoxine antibodies. Prudent use of sulfadoxine containing drugs is advocated.http://omjournal.org/articleDetails.aspx?coType=1&aId=1964SulfadoxineAntibodiesMalariaDemographyPrevalenceBeninNigeria |
| spellingShingle | Kingsley Ikuoyogie Helen Oroboghae Ogefere Richard Omoregie Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria Oman Medical Journal Sulfadoxine Antibodies Malaria Demography Prevalence Benin Nigeria |
| title | Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria |
| title_full | Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria |
| title_fullStr | Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria |
| title_full_unstemmed | Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria |
| title_short | Prevalence and Risk Factors for Sulfadoxine Antibody Among Patients Undergoing Treatment for Malaria in Benin City, Nigeria |
| title_sort | prevalence and risk factors for sulfadoxine antibody among patients undergoing treatment for malaria in benin city nigeria |
| topic | Sulfadoxine Antibodies Malaria Demography Prevalence Benin Nigeria |
| url | http://omjournal.org/articleDetails.aspx?coType=1&aId=1964 |
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