Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis
Background: Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery disease (CAD). Methods: Medline, Web of Science a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906723000222 |
| _version_ | 1797854553587056640 |
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| author | Muhammad U. Siddiqui Joey Junarta Swaminathan Sathyanarayanan Kirpal Kochar Waqas Ullah David L. Fischman |
| author_facet | Muhammad U. Siddiqui Joey Junarta Swaminathan Sathyanarayanan Kirpal Kochar Waqas Ullah David L. Fischman |
| author_sort | Muhammad U. Siddiqui |
| collection | DOAJ |
| description | Background: Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery disease (CAD). Methods: Medline, Web of Science and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary outcomes included myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Secondary outcomes included stroke and all-cause mortality. Results: We included 4 observational studies comprising 10,026 patients with gout on treatment with colchicine. There was no significant difference in the risk of myocardial infarction (risk ratio [RR] 0.71; 95% confidence interval [CI], 0.36–1.39), need for PCI, or need for CABG, between patients on colchicine and those not receiving colchicine. Colchicine was associated with a significantly lower risk of all-cause mortality (RR 0.58; 95% CI 0.43–0.79). Conclusion: Non-randomized studies suggest that risk of MI, stroke and revascularization is not higher in gout patients treated with colchicine compared to gout patients without colchicine treatment. |
| first_indexed | 2024-04-09T20:07:54Z |
| format | Article |
| id | doaj.art-b40fb5696131435580c3bbc4d057c9ac |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-09T20:07:54Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-b40fb5696131435580c3bbc4d057c9ac2023-04-01T08:50:24ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-04-0145101191Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysisMuhammad U. Siddiqui0Joey Junarta1Swaminathan Sathyanarayanan2Kirpal Kochar3Waqas Ullah4David L. Fischman5Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA; Corresponding author at: Department of Internal Medicine, Thomas Jefferson University Hospitals, 833 Chestnut Street, Suite 701, Philadelphia, Pennsylvania 19107, USA.Division of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USASanford School of Medicine, University of South Dakota, USADivision of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USAJefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USAJefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USABackground: Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery disease (CAD). Methods: Medline, Web of Science and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary outcomes included myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Secondary outcomes included stroke and all-cause mortality. Results: We included 4 observational studies comprising 10,026 patients with gout on treatment with colchicine. There was no significant difference in the risk of myocardial infarction (risk ratio [RR] 0.71; 95% confidence interval [CI], 0.36–1.39), need for PCI, or need for CABG, between patients on colchicine and those not receiving colchicine. Colchicine was associated with a significantly lower risk of all-cause mortality (RR 0.58; 95% CI 0.43–0.79). Conclusion: Non-randomized studies suggest that risk of MI, stroke and revascularization is not higher in gout patients treated with colchicine compared to gout patients without colchicine treatment.http://www.sciencedirect.com/science/article/pii/S2352906723000222Coronary Artery DiseaseMyocardial InfarctionGoutColchicine |
| spellingShingle | Muhammad U. Siddiqui Joey Junarta Swaminathan Sathyanarayanan Kirpal Kochar Waqas Ullah David L. Fischman Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis International Journal of Cardiology: Heart & Vasculature Coronary Artery Disease Myocardial Infarction Gout Colchicine |
| title | Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis |
| title_full | Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis |
| title_fullStr | Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis |
| title_full_unstemmed | Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis |
| title_short | Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis |
| title_sort | risk of coronary artery disease in patients with gout on treatment with colchicine a systematic review and meta analysis |
| topic | Coronary Artery Disease Myocardial Infarction Gout Colchicine |
| url | http://www.sciencedirect.com/science/article/pii/S2352906723000222 |
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