A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager
Synovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1288213/full |
| _version_ | 1797305249689501696 |
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| author | Yan Liu Manman Cui Xiuzhi Zhou Duchang Zhai Mingyu Qin Guohua Fan Wu Cai |
| author_facet | Yan Liu Manman Cui Xiuzhi Zhou Duchang Zhai Mingyu Qin Guohua Fan Wu Cai |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | Synovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old teenager who initially presented with cough as the primary symptom. In this case, plain chest CT and contrast-enhanced CT clearly revealed the lesion presenting as a round-like and uneven density mass in the mediastinum with heterogeneous enhancement, which compressed the trachea and invaded the adjacent vessels. Based on the results of immunohistochemistry and fluorescence in situ hybridization (FISH), combined with the differential diagnosis with other types of tumors in the mediastinum on imaging, we were able to diagnose the tumor as an SS located in the mediastinum. Subsequent resection of the lesion coupled with chemotherapy and immunotherapy led to an improvement in the patient’s symptoms. |
| first_indexed | 2024-03-08T00:22:13Z |
| format | Article |
| id | doaj.art-b40fcc06f15d426597a974d859e55db1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T00:22:13Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b40fcc06f15d426597a974d859e55db12024-02-16T04:42:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.12882131288213A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenagerYan Liu0Manman Cui1Xiuzhi Zhou2Duchang Zhai3Mingyu Qin4Guohua Fan5Wu Cai6Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaSuzhou Medical College, Soochow University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaSynovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old teenager who initially presented with cough as the primary symptom. In this case, plain chest CT and contrast-enhanced CT clearly revealed the lesion presenting as a round-like and uneven density mass in the mediastinum with heterogeneous enhancement, which compressed the trachea and invaded the adjacent vessels. Based on the results of immunohistochemistry and fluorescence in situ hybridization (FISH), combined with the differential diagnosis with other types of tumors in the mediastinum on imaging, we were able to diagnose the tumor as an SS located in the mediastinum. Subsequent resection of the lesion coupled with chemotherapy and immunotherapy led to an improvement in the patient’s symptoms.https://www.frontiersin.org/articles/10.3389/fonc.2024.1288213/fullsynovial sarcomamediastinummesenchymal cellchest imagingoncology |
| spellingShingle | Yan Liu Manman Cui Xiuzhi Zhou Duchang Zhai Mingyu Qin Guohua Fan Wu Cai A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager Frontiers in Oncology synovial sarcoma mediastinum mesenchymal cell chest imaging oncology |
| title | A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager |
| title_full | A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager |
| title_fullStr | A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager |
| title_full_unstemmed | A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager |
| title_short | A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager |
| title_sort | case report synovial sarcoma of the mediastinum in an 18 year old teenager |
| topic | synovial sarcoma mediastinum mesenchymal cell chest imaging oncology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1288213/full |
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